Hepcidin

Hepcidin is a antibacterial and anti-fungal protein expressed in the liver and is also a signalling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin [PMID: 12138110].

The below sequences were used to create Hepcidin sequence signatures:

> HepcidinH20_4, HepcidinH_22, HepcidinP20_4 | CAMPSQ4 | P81172 | 10863973
 ICIFCCGCCHRSKCGMCCKT
> HepcidinH21_2, HepcidinH_22, HepcidinP21_2 | CAMPSQ240 | P82951 | 21542075
 GCRFCCNCCPNMSGCGVCCRF
> HepcidinH25_6, HepcidinH_22, HepcidinP25_6 | CAMPSQ983 | P81172 | 159162673
 DTHFPICIFCCGCCHRSKCGMCCKT
> HepcidinH21_2, HepcidinH_22, HepcidinP21_2 | CAMPSQ1098 | A1Z0M0 | 223635234
 RCRFCCRCCPRMRGCGICCRF
> HepcidinH25_6, HepcidinH_22, HepcidinP25_6 | CAMPSQ1533 | Q9EQ21 | 21542093
 DTNFPICIFCCKCCNNSQCGICCKT
> HepcidinH20_4, HepcidinH_22, HepcidinP20_4 | CAMPSQ2895 | |
CRFCCRCCPRMRGCGLCCRF
> HepcidinH_22 | CAMPSQ2896 | |
GIKCRFCCGCCTPGICGVCCRF
> HepcidinH20_4, HepcidinH_22, HepcidinP20_4 | CAMPSQ2897 | |
QSHLSLCRWCCNCCRSNKGC
> HepcidinH24_2, HepcidinH_22, HepcidinP24_2 | CAMPSQ3425 | |
SPAGCRFCCGCCPNMRGCGVCCRF
> HepcidinH_22 | CAMPSQ3428 | D3Y2R5 | 289431952
 MKTFSVAVAVAIVLAFICTQESSALPVTGVEELVELVSSDDPVADHQELPVELGERLFNI
RKKRASPKCTPYCYPTRDGVFCGVRCDF
> HepcidinH_22 | CAMPSQ3429 | D3Y2R6 | 289431954
 MKTFSVAVAVAVVLAFICTQESSALPVTGIEELVEPVSSDNNDNHQGLPVELRERLVNIR
KKRAPTDCIPYCYPTGDGFHCGVTCRF
> HepcidinH31_2, HepcidinH_22, HepcidinP31_2 | CAMPSQ3812 | |
APAKCTPYCYPTRDGVFCGVRCDFQHHHHHH
> HepcidinH_22 | CAMPSQ4289 | E8ZAD0 | 282167192
 MKVLAACVFLLLLVLLHGSPAACSALRAQANIGLMPRPETGAQSHGLEAAAGLMPHPEIG
AQSLEVPLRRSKRFNSHFPICSYCCNCCRNKGCGLCCRT
> HepcidinH25_6, HepcidinH_22, HepcidinP25_6 | CAMPSQ8887 | |
QSHLSLCRWCCNCCHNKGCGFCCKF
> HepcidinH_22 | CAMPSQ10878 | |
QSHLSMCRYCCNCCRNNKGCGFCCKF
> HepcidinH24_2, HepcidinH_22, HepcidinP24_2 | CAMPSQ10879 | |
NPAGCRFCCGCCPNMIGCGVCCRF
> HepcidinH_22 | CAMPSQ11272 | |
MRTYLKTMLLAGLASLLLVAQAERALTSMDALDAAIEFYNRASEHDHAFKQASLFNLQET
VCLKSENYEKPKCTFMENGLLLKCSALVSVLKESSAFANIAVTCDTSIPNKQEVARVKRG
GNGSRGREGGRPGSRSSTGKPSKSLNFVERLL
> HepcidinH25_6, HepcidinH_22, HepcidinP25_6 | CAMPSQ11275 | |
QSHFPICLYCCNCCKNKGCGYCCRT
> HepcidinH25_6, HepcidinH_22, HepcidinP25_6 | CAMPSQ11456 | |
QSHLSLCRYCCNCCRNKGCGYCCKF
> HepcidinH25_6, HepcidinH_22, HepcidinP25_6 | CAMPSQ12607 | Q8MJ80 | 47605566
 DTHFPICIFCCGCCRKAICGMCCKT
> HepcidinH31_2, HepcidinH_22, HepcidinP31_2 | CAMPSQ14223 | |
SPAGRNSRRRRCRFCCGCCPDMVGCGTCCKF
> HepcidinH20_4, HepcidinH_22, HepcidinP20_4 | CAMPSQ14224 | |
CRFCCGCCPDMVGCGTCCKF

The below sequences were retrieved using Hepcidin sequence signatures:

> HepcidinH_22, HepcidinH20_4, HepcidinH25_6, HepcidinP20_4, HepcidinP25_6 | CAMPSQ4 | P81172 | 10863973
 ICIFCCGCCHRSKCGMCCKT
> HepcidinH_22, HepcidinH20_4, HepcidinH21_2, HepcidinH24_2, HepcidinH31_2, HepcidinP20_4, HepcidinP21_2 | CAMPSQ240 | P82951 | 21542075
 GCRFCCNCCPNMSGCGVCCRF
> HepcidinH_22, HepcidinH20_4, HepcidinH25_6, HepcidinP20_4, HepcidinP25_6 | CAMPSQ983 | P81172 | 159162673
 DTHFPICIFCCGCCHRSKCGMCCKT
> HepcidinH_22, HepcidinH20_4, HepcidinH21_2, HepcidinH24_2, HepcidinH31_2, HepcidinP20_4, HepcidinP21_2 | CAMPSQ1098 | A1Z0M0 | 223635234
 RCRFCCRCCPRMRGCGICCRF
> HepcidinH_22, HepcidinH20_4, HepcidinH25_6, HepcidinP20_4, HepcidinP25_6 | CAMPSQ1464 | Q5U9D2 | 58761191
 PHQTGQLTDLRAQDTAGAEAGLQPTLQLRRLRRRDTHFPICIFCCGCCKTPKCGFCCKT
> HepcidinH_22, HepcidinH20_4, HepcidinH25_6, HepcidinP20_4, HepcidinP25_6 | CAMPSQ1533 | Q9EQ21 | 21542093
 DTNFPICIFCCKCCNNSQCGICCKT
> HepcidinH_22, HepcidinH20_4, HepcidinH25_6, HepcidinP20_4, HepcidinP25_6 | CAMPSQ1682 | Q7T273 | 45387595
 LCRFCCKCCRNKGCGYCCKF
> HepcidinH_22, HepcidinH20_4, HepcidinH25_6, HepcidinP20_4, HepcidinP25_6 | CAMPSQ1684 | Q5U9D2 | 62900176
 PHQTGQLTDLRAQDTAGAEAGLQPTLQLRRLRRRDTHFPICIFCCGCCKTPKCGLCCKT
> HepcidinH_22, HepcidinH20_4, HepcidinH25_6, HepcidinP20_4, HepcidinP25_6 | CAMPSQ1685 | Q7T273, P61516 | 143811401, 47605599
 QSHLSLCRFCCKCCRNKGCGYCCKF
> HepcidinH_22, HepcidinH25_6, HepcidinP20_4 | CAMPSQ1686 | Q99MH3 | 21542070
 DTNFPICLFCCKCCKNSSCGLCCIT
> HepcidinH_22, HepcidinH20_4, HepcidinH25_6 | CAMPSQ1687 | Q9DFD6 | 21542090
 XSHLSLCRWCCNCCHNKGXGFCCKF
> HepcidinH_22, HepcidinH25_6 | CAMPSQ1813 | Q801Y3 | 47605662
 QIHLSLCGLCCNCCHNIGCGFCCKF
> HepcidinH_22, HepcidinH20_4, HepcidinH25_6 | CAMPSQ1899 | Q5NVR8 | 75040808
 DTHFPIYIFCCGCCHRSKCGMCCKT
> HepcidinH_22, HepcidinH25_6, HepcidinP20_4 | CAMPSQ1901 | Q80T19 | 47605663
 DINFPICRFCCQCCNKPSCGICCEE
> HepcidinH_22, HepcidinH20_4, HepcidinH25_6, HepcidinP20_4, HepcidinP25_6 | CAMPSQ12607 | Q8MJ80 | 47605566
 DTHFPICIFCCGCCRKAICGMCCKT
> HepcidinH_22, HepcidinH20_4, HepcidinH25_6, HepcidinP20_4, HepcidinP25_6 | CAMPSQ15989 | P61516 |
MKLSNVFLAAVVILTCVCVFQITAVPFIQQVQDEHHVESEELQENQHLTEAEHRQTDPLV
LFRTKRQSHLSLCRFCCKCCRNKGCGYCCKF
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