CAMPSQ1533
Title : Hepcidin
GenInfo Identifier : 21542093
Source : Mus musculus [Mouse]
Taxonomy : Animalia, Mammals
UniProt: Q9EQ21
Activity : Antimicrobial
Validated : Experimentally validated
Pfam : PF06446 : Hepcidin ( Hepcidin )
InterPro : IPR010500 : Hepcidin.
AMP Family : Hepcidin
Signature :
ID Type Pattern / HMM
HepcidinH25_6 HMM
HepcidinH_22 HMM
HepcidinP25_6 Pattern C-x-[FWY]-C-C-x-C-C-x(4)-C-G-x-C-C-[KR]
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0045179 Cellular component Apical cortex ISO
GO:0005737 Cellular component Cytoplasm ISO
GO:0005576 Cellular component Extracellular region IDA
GO:0005615 Cellular component Extracellular space IDA
GO:0014704 Cellular component Intercalated disc ISO
GO:0005634 Cellular component Nucleus IDA
GO:0005507 Molecular function Copper ion binding IDA
GO:0005179 Molecular function Hormone activity ISO
GO:0097690 Molecular function Iron ion transmembrane transporter inhibitor activity ISO
GO:0005102 Molecular function Signaling receptor binding ISO
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide ISO
GO:0006879 Biological process Cellular iron ion homeostasis IDA
GO:0031668 Biological process Cellular response to extracellular stimulus TAS
GO:0042742 Biological process Defense response to bacterium IDA
GO:0050832 Biological process Defense response to fungus IDA
GO:0050829 Biological process Defense response to Gram-negative bacterium ISO
GO:0050830 Biological process Defense response to Gram-positive bacterium ISO
GO:0055072 Biological process Iron ion homeostasis IDA
GO:0031640 Biological process Killing of cells of other organism ISO
GO:0060586 Biological process Multicellular organismal iron ion homeostasis ISO
GO:0002262 Biological process Myeloid cell homeostasis IMP
GO:0045779 Biological process Negative regulation of bone resorption IMP
GO:0050728 Biological process Negative regulation of inflammatory response IGI
GO:1904479 Biological process Negative regulation of intestinal absorption ISO
GO:0032413 Biological process Negative regulation of ion transmembrane transporter activity ISO
GO:1904039 Biological process Negative regulation of iron export across plasma membrane ISO
GO:0034760 Biological process Negative regulation of iron ion transmembrane transport IGI
GO:1904255 Biological process Negative regulation of iron ion transmembrane transporter activity ISO
GO:0000122 Biological process Negative regulation of transcription by RNA polymerase II IMP
GO:0061051 Biological process Positive regulation of cell growth involved in cardiac muscle cell development ISO
GO:1903364 Biological process Positive regulation of cellular protein catabolic process IDA
GO:0043032 Biological process Positive regulation of macrophage activation IMP
GO:1902916 Biological process Positive regulation of protein polyubiquitination ISO
GO:2000646 Biological process Positive regulation of receptor catabolic process ISO
GO:0002092 Biological process Positive regulation of receptor internalization ISO
GO:0045944 Biological process Positive regulation of transcription by RNA polymerase II IGI
GO:0007259 Biological process Receptor signaling pathway via JAK-STAT IDA
GO:0010039 Biological process Response to iron ion ISO
Length : 25
Sequence:
 DTNFPICIFCCKCCNNSQCGICCKT

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