CAMPSQ7545
Title : Interferon-induced guanylate-binding protein 2
Source : Homo sapiens [Human]
Taxonomy : Animalia, Mammals
UniProt: P32456
Activity : Antiviral
Validated : Predicted
Pfam : PF02263 : GBP ( Guanylate-binding protein, N-terminal domain )
PF02841 : GBP_C ( Guanylate-binding protein, C-terminal domain )
InterPro : IPR030386 :
IPR003191 :
IPR015894 :
IPR027417 :
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005737 Cellular component Cytoplasm IDA
GO:0031410 Cellular component Cytoplasmic vesicle ISS
GO:0005829 Cellular component Cytosol IDA
GO:0005794 Cellular component Golgi apparatus IDA
GO:0000139 Cellular component Golgi membrane IEA
GO:0005654 Cellular component Nucleoplasm IDA
GO:0005634 Cellular component Nucleus IDA
GO:0048471 Cellular component Perinuclear region of cytoplasm IDA
GO:0005525 Molecular function GTP binding IBA
GO:0003924 Molecular function GTPase activity IBA
GO:0042802 Molecular function Identical protein binding IPI
GO:0042803 Molecular function Protein homodimerization activity IDA
GO:0071346 Biological process Cellular response to interferon-gamma IDA
GO:0071347 Biological process Cellular response to interleukin-1 IEP
GO:0071356 Biological process Cellular response to tumor necrosis factor IEP
GO:0050830 Biological process Defense response to Gram-positive bacterium IBA
GO:0042832 Biological process Defense response to protozoan IBA
GO:0006955 Biological process Immune response TAS
GO:0034504 Biological process Protein localization to nucleus IDA
Length : 588
Sequence:
 MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
KKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAI
LLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTL
RDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPA
PKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVN
AISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSER
EAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDV
KQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSL
SEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQL
MAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPIC

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