CAMPSQ7512
Title : Paneth cell-specific alpha-defensin 1
GenInfo Identifier : 810515334
Source : Equus caballus [horse ]
Taxonomy : Animalia, Mammals
UniProt: A6YB85
PDB: 2MXQ
Structure Database : CAMPST730
PubMed : 17620056
Activity : Antibacterial, Antifungal
Gram Nature : Gram +ve, Gram -ve
Target :
E. coli ATCC 11775 ( LD 90 = 0.2 microM ), E. coli ATCC 25922 ( LD 90 = 0.2 microM ), E. coli ATCC 35218 ( LD 90 = 0.05 microM ), E. coli D31 ( LD 90 = 0.4 microM ), K. pneumoniae ATCC 13883 ( LD 90 = 3 microM ), E. cloacae ATCC 13047 ( LD 90 = 6.1 microM ), P. aeruginosa ATCC 10145 ( LD 90 = 3 microM ), P. aeruginosa ATCC 11440 ( LD 90 = 1.5 microM ), S. aureus ATCC 6538 ( LD 90 = 0.4 microM ), S. aureus ATCC 12600 ( LD 90 = 0.4 microM ), S. epidermidis ATCC 14990 ( LD 90 = 0.8 microM ), E. faecalis ATCC 29212 ( LD 90 = 0.2 microM ), E. faecalis PEG 205 (wild-type) ( LD 90 = 0.4 microM ), S. pyogenes ATCC 12344 ( LD 90 = 0.8 microM ), B. megaterium A.T.C.C. 14581 ( LD 90 = 0.05 microM ), C. albicans ATCC 24433 ( LD 90 = 0.8 microM )
Validated : Experimentally validated
Pfam : PF00323 : Defensin_1 ( Mammalian defensin )
PF00879 : Defensin_propep ( Defensin propeptide )
InterPro : IPR016327 : Alpha-defensin.
IPR016327 :
IPR002366 : Defensin_propep.
IPR002366 :
IPR006081 : Mammalian_defensins.
IPR006081 :
AMP Family : Defensin
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005615 Cellular component Extracellular space IBA
GO:0005543 Molecular function Phospholipid binding IDA
GO:0019731 Biological process Antibacterial humoral response IBA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IBA
GO:0071222 Biological process Cellular response to lipopolysaccharide IBA
GO:0042742 Biological process Defense response to bacterium IDA
GO:0050829 Biological process Defense response to Gram-negative bacterium IBA
GO:0050830 Biological process Defense response to Gram-positive bacterium IBA
GO:0002227 Biological process Innate immune response in mucosa IBA
GO:0051673 Biological process Membrane disruption in other organism IBA
Length : 34
Sequence:
 SCTCRRAWICRWGERHSGKCIDQKGSTYRLCCRR

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