CAMPSQ396
Title : Neutrophil defensin 4
GenInfo Identifier : 399352
Source : Homo sapiens [Human]
Taxonomy : Animalia, Mammals
UniProt: P12838
PDB: 1ZMM
Structure Database : CAMPST95
PubMed : 2500436, 17088326, 30658057
Activity : Antibacterial, Antifungal
Gram Nature : Gram +ve, Gram -ve
Target :
[ Refer : 2500436 E. coli (1.2 x l04 colony forming units/ml with an LD50 of 0.085 microg/ml), S. faecalis (3.1 X l04 colony forming units/ml with an LD50 of 2.38 microg/ml), and C. albicans (8 X l03 colony forming units/ml with an LD50 of 0.515 microg/ml) ] [ Refer : 17088326 E. coli ATCC 25922 ( IC99 = 19.0 +/- 4.1 microg/ml) , S. aureus ATCC 29123 ( IC99 >100 microg/ml) , C. albicans ATCC 99788 amphotericin B resistant ( IC90 > 100 microg/ml) ], [ Refer: 30658057 Active against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213]
Validated : Experimentally validated
Pfam : PF00323 : Defensin_1 ( Mammalian defensin )
PF00879 : Defensin_propep ( Defensin propeptide )
InterPro : IPR016327 : Alpha-defensin.
IPR016327 :
IPR006080 : Defensin_beta/neutrophil.
IPR006080 :
IPR002366 : Defensin_propep.
IPR002366 :
IPR006081 : Mammalian_defensins.
IPR006081 :
AMP Family : Defensin
Signature :
ID Type Pattern / HMM
DefensinH33_12 HMM
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0042582 Cellular component Azurophil granule IDA
GO:0005576 Cellular component Extracellular region TAS
GO:0005615 Cellular component Extracellular space IBA
GO:0005796 Cellular component Golgi lumen TAS
GO:0035580 Cellular component Specific granule lumen TAS
GO:0042803 Molecular function Protein homodimerization activity IDA
GO:0019731 Biological process Antibacterial humoral response IDA
GO:0019732 Biological process Antifungal humoral response IDA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IDA
GO:0019730 Biological process Antimicrobial humoral response IDA
GO:0071222 Biological process Cellular response to lipopolysaccharide IBA
GO:0050832 Biological process Defense response to fungus IDA
GO:0050829 Biological process Defense response to Gram-negative bacterium IDA
GO:0050830 Biological process Defense response to Gram-positive bacterium IDA
GO:0045087 Biological process Innate immune response IDA
GO:0002227 Biological process Innate immune response in mucosa IBA
GO:0031640 Biological process Killing of cells of other organism IDA
GO:0051673 Biological process Membrane disruption in other organism IBA
GO:0010818 Biological process T cell chemotaxis IDA
GO:0042582 Cellular component Azurophil granule IDA
GO:0005576 Cellular component Extracellular region TAS
GO:0005615 Cellular component Extracellular space IBA
GO:0005796 Cellular component Golgi lumen TAS
GO:0035580 Cellular component Specific granule lumen TAS
GO:0030133 Cellular component Transport vesicle IEA
GO:0042803 Molecular function Protein homodimerization activity IDA
GO:0019731 Biological process Antibacterial humoral response IDA
GO:0019732 Biological process Antifungal humoral response IDA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IDA
GO:0019730 Biological process Antimicrobial humoral response IDA
GO:0071222 Biological process Cellular response to lipopolysaccharide IBA
GO:0050832 Biological process Defense response to fungus IDA
GO:0050829 Biological process Defense response to Gram-negative bacterium IDA
GO:0050830 Biological process Defense response to Gram-positive bacterium IDA
GO:0045087 Biological process Innate immune response IDA
GO:0002227 Biological process Innate immune response in mucosa IBA
GO:0031640 Biological process Killing of cells of another organism IDA
GO:0051673 Biological process Membrane disruption in another organism IBA
GO:0010818 Biological process T cell chemotaxis IDA
Length : 33
Sequence:
 VCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRV

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