CAMPSQ2640
Title : Temporin-SHf precursor, partial
GenInfo Identifier : 295004058
Source : Pelophylax saharicus [Sahara frog]
Taxonomy : Animalia, Amphibia
UniProt: D4YWD1
PubMed : 20308076
Activity : Antibacterial, Antifungal
Gram Nature : Gram +ve, Gram -ve
Target :
E. coli ATCC 25922 (MIC = 25 microM), E. coli ATCC 35218 (MIC >200 microM), E. coli D21 (MIC = 100 microM), E. coli ML-35p (MIC = 30 microM), P. aeruginosa ATCC 27853 (MIC >200 microM), S. aureus ATCC 25923 (MIC = 12.5 microM), E. faecalis ATCC 29212 (MIC = 50 microM), B. megaterium (MIC = 3 microM), C. albicans ATCC 90028 (MIC=50 microM), C. parapsilosis ATCC 22019 (MIC=50 microM), S. cerevisiae (MIC=12.5 microM), A. flavus (MIC>200 microM)
Hemolytic Activity :
Present but temporin-SHf is not cytotoxic against human erythrocytes (LC50 = 200 μm), with a hemolytic activity detected only at peptide concentration far above the MIC values determined for the sensitive strains (3 €“50 μm)
Validated : Experimentally validated
Comment : Also Anti-Protozoan
Pfam : PF03032 : FSAP_sig_propep ( Brevenin/esculentin/gaegurin/rugosin family )
InterPro : IPR004275 : Brevinin.
IPR004275 :
AMP Family : Temporin
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular component Extracellular region IEA
GO:0016020 Cellular component Membrane IEA
GO:0042742 Biological process Defense response to bacterium IEA
GO:0044179 Biological process Hemolysis in other organism IEA
GO:0045087 Biological process Innate immune response IEA
GO:0005576 Cellular component Extracellular region IEA
GO:0016020 Cellular component Membrane IEA
GO:0044218 Cellular component Other organism cell membrane IEA
GO:0042742 Biological process Defense response to bacterium IEA
GO:0044179 Biological process Hemolysis in another organism IEA
GO:0045087 Biological process Innate immune response IEA
Length : 9
Sequence:
FFLSRIFGK

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