CAMPSQ254
Title : Indolicidin
GenInfo Identifier : 246037
Source : Bos taurus [Bovine]
Taxonomy : Animalia, Mammals
UniProt: P33046
PDB: 1G89, 1G8C, 1HR1, 1QX9, 1QXQ
Structure Database : CAMPST26, CAMPST27, CAMPST28, CAMPST63, CAMPST64
PubMed : 1537821, 19191872, 35254120
Activity : Antibacterial
Gram Nature : Gram +ve, Gram -ve
Target :
Escherichia col ML35, Staphylococcus aureus 502Ai; [Refer PubMed ID: 19191872: E. coli( MIC= 20microg/ml), P. aeruginosa(MIC= 40microg/ml), S. typhimurium(MIC= 20microg/ml), B. subtilis(MIC= 10microg/ml), S. epidermidis (MIC= 20microg/ml), S. aureus(MIC= 5microg/ml)]; [Refer PubMed ID: 35254120: K. pneumoniae strains NTUH-K2044 (K1 capsule) (MIC = 32 microg/ml), ATCC 43816 (K2 capsule) (MIC = 16 microg/ml), ATCC 13883 (K3 capsule) (MIC = 32 microg/ml), ATCC 700603 (K6 capsule) (MIC = 16 microg/ml), MKP103 (K107 capsule) (MIC = >128 microg/ml), MKP103 wza mutant (MIC = >128 microg/ml)]
Hemolytic Activity :
hRBC(50% hemolysis at 200microg/ml)
Validated : Experimentally validated
Comment : C terminal: NH2
InterPro : IPR001894 : Cathelicidin.
IPR001894 :
IPR018216 : Cathelicidin_CS.
IPR018216 :
AMP Family : Cathelicidin
Signature :
ID Type Pattern / HMM
CathelicidinH13_4 HMM
CathelicidinH_140 HMM
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005615 Cellular component Extracellular space IBA
GO:0001530 Molecular function Lipopolysaccharide binding IBA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IDA
GO:0050832 Biological process Defense response to fungus IEA
GO:0050829 Biological process Defense response to Gram-negative bacterium IBA
GO:0050830 Biological process Defense response to Gram-positive bacterium IBA
GO:0045087 Biological process Innate immune response IBA
GO:0031640 Biological process Killing of cells of other organism IDA
GO:0005615 Cellular component Extracellular space IBA
GO:0001530 Molecular function Lipopolysaccharide binding IBA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IDA
GO:0050832 Biological process Defense response to fungus IEA
GO:0050829 Biological process Defense response to Gram-negative bacterium IBA
GO:0050830 Biological process Defense response to Gram-positive bacterium IBA
GO:0045087 Biological process Innate immune response IBA
GO:0031640 Biological process Killing of cells of another organism IDA
Length : 13
Sequence:
 ILPWKWPWWPWRR

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