CAMPSQ19042
Title : D-SMAP-29-1
Source : Ovis aries
UniProt: P49928, P49929,
PDB: 1FRY
Structure Database : CAMPST23
PubMed : 11600395, 16997510, 14742236, 10601638, 24221355, 19396584
Activity : Antibacterial
Gram Nature : Gram+, Gram-
Target :
Mannheimia haemolytica Serovar 1[MIC = 0.9+-0.3 microg/ml], Mannheimia haemolytica Serovar 1[MBC = 0.5+-0.1 microg/ml], Mannheimia haemolytica Serovar 2[MIC = 1.7+-0.4 microg/ml], Mannheimia haemolytica Serovar 2[MBC = 0.6+-0.0 microg/ml], Mannheimia haemolytica Serovar 6[MIC = 0.6+-0.0 microg/ml], Mannheimia haemolytica Serovar 6[MBC = 0.6+-0.0 microg/ml], Bibersteinia trehalosi[MIC = 1.3+-0.0 microg/ml], Bibersteinia trehalosi[MBC = 0.8+-0.2 microg/ml], Salmonella enterica subsp. arizonae[MIC = 1.3+-0.0 microg/ml], Salmonella enterica subsp. arizonae[MBC = 2.1+-0.4 microg/ml], Pasteurella multocida[MIC = 0.3+-0.0 microg/ml], Pasteurella multocida[MBC = 0.3+-0.0 microg/ml], Klebsiella pneumoniae[MIC = 0.4+-0.2 microg/ml], Klebsiella pneumoniae[MBC = 0.4+-0.2 microg/ml], Corynebacterium pseudotuberculosis ATCC 19410[MIC = 20.0+-0.0 microg/ml], Corynebacterium pseudotuberculosis ATCC 19410[MBC >=20.0 microg/ml], Staphylococcus aureus[MIC = 1.3+-0.0 microg/ml], Staphylococcus aureus[MBC = 1.0+-0.2 microg/ml], Aspergillus fumigatus[MIC = 5.0+-0.0 microg/ml], Aspergillus fumigatus[MBC = 11.7+-4.4 microg/ml], Escherichia coli O111[MIC = 2 microg/ml], Escherichia coli UB1005[MIC = 0.125 microg/ml], Escherichia coli DC2[MIC = 0.125 microg/ml], Escherichia coli O157:H7[MIC = 2 microg/ml], Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028s[MIC = 0.25 microg/ml], Salmonella enterica serovar Typhimurium MS4252S[MIC = 0.125 microg/ml], Pseudomonas aeruginosa PAO1[MIC = 4 microg/ml], Pseudomonas aeruginosa Z61[MIC = 1 microg/ml], Staphylococcus aureus NCTC 4163[MIC = 1 microg/ml], Staphylococcus aureus R147[MIC = 0.5 microg/ml], Staphylococcus aureus 1056[MIC = 4 microg/ml], Staphylococcus epidermidis[MIC = 0.25 microg/ml], Enterococcus faecalis ATCC 29212[MIC = 2 microg/ml], Candida albicans 105[MIC = 2 microg/ml], Candida albicans 3153A[MIC = 4 microg/ml], Escherichia coli ML-35[MIC = 0.25 microM], Escherichia coli D21[MIC = 0.12 microM], Pseudomonas aeruginosa[MIC = 0.25-2.0 microM], Serratia marcescens ATCC 8100[MIC = 0.25 microM], Proteus vulgaris ATCC 13315[MIC >80 microM], Staphylococcus aureus Cowan 1[MIC = 0.5 microM], Staphylococcus aureus[MIC = 1 microM], Staphylococcus epidermidis ATCC 12228[MIC = 0.25 microM], Enterococcus faecalis[MIC = 1 microM], Bacillus megaterium Bm11[MIC = 0.25 microM], Candida albicans[MIC = 4 microM], Cryptococcus neoformans[MIC = 1 microM], Rhodotorula mucilaginosa[MIC = 0.5 microM], Escherichia coli ATCC 25922[MIC = 1.56 microM], Escherichia coli O157:H7 ATCC 700728[MIC = 0.78 microM], Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028[MIC = 0.39 microM], Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700408[MIC = 0.39 microM], Klebsiella pneumoniae ATCC 13883[MIC = 0.39 microM], Pseudomonas aeruginosa ATCC 27853[MIC = 3.12 microM], Listeria monocytogenes ATCC 19115[MIC = 0.78 microM], Staphylococcus aureus ATCC 25923[MIC = 0.78 microM], Staphylococcus aureus ATCC BAA-39[MIC = 0.39 microM], Staphylococcus aureus ATCC 43300[MIC = 0.39 microM], Bacillus subtilis KCTC 3068[MIC = 2 microM], Bacillus subtilis KCTC 3068[MIC = 1 microM], Staphylococcus aureus KCTC 1916[MIC = 0.5 microM], Micrococcus luteus KCTC 1071[MIC = 1 microM], Staphylococcus epidermidis KCTC 1917[MIC = 0.5 microM], Escherichia coli KCTC 1682[MIC = 2 microM], Escherichia coli KCTC 1682[MIC = 1 microM], Salmonella typhimurium KCTC 1926[MIC = 1 microM], Salmonella typhimurium KCTC 1926[MIC = 0.5 microM], Pseudomonas aeruginosa KCTC 1637[MIC = 4 microM], Pseudomonas aeruginosa KCTC 1637[MIC = 2 microM], Candida albicans KCTC 7965[MIC = 2 microM], Candida albicans KCTC 7965[MIC = 8 microM], Escherichia coli ATCC 12795[MIC = 0.1 microM], Escherichia coli ATCC 12795[MBC = 0.1 microM], Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028[MIC = 0.78 microg/ml], Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700408[MIC = 0.78 microg/ml], Pseudomonas aeruginosa KCTC 1637[MIC = 02-4 microM], Staphylococcus epidermidis KCTC 1917[MIC = 01-2microM], Staphylococcus aureus KCTC 1621[MIC = 01-2microM], Murine macrophage cells RAW 264.7[IC50 = 20 microM], Human cervical carcinoma HeLa[IC50 = 30 microM], Staphylococcus aureus CCARM 3089[MIC = 4 microM], Staphylococcus aureus CCARM 3090[MIC = 2 microM], Staphylococcus aureus CCARM 3095[MIC = 2 microM], Escherichia coli O157:H7[MIC = 3.4 microg/ml], Staphylococcus aureus 1056[MIC = 4.6 microg/ml], Escherichia coli KCTC 1682[MIC = 4 microM], Salmonella typhimurium KCTC 1926[MIC = 2 microM], Staphylococcus epidermidis KCTC 1917[MIC = 2 microM], Staphylococcus aureus KCTC 1621[MIC = 2 microM], Staphylococcus aureus CCARM 3090[MIC = 4 microM], Bacillus subtilis KCTC 3068[MIC = 4 microM], Staphylococcus epidermidis KCTC 1917[MIC = 4 microM], Staphylococcus aureus KCTC 1621[MIC = 4 microM], Staphylococcus aureus CCARM 3095[MIC = 4 microM]
Hemolytic Activity :
Human erythrocytes (4% Hemolysis at 4 microM, Human erythrocytes (19% Hemolysis at 20 microM, Human erythrocytes (67% Hemolysis at 80 microM, Human erythrocytes (50% Hemolysis at 86 microM, Human erythrocytes (10% Hemolysis at 6 microM, Human erythrocytes (10% Hemolysis at 5.5 microM, Human erythrocytes (10% Hemolysis at 110 microM
Validated : Experimentally Validated
InterPro : IPR001894 : Cathelicidin.
IPR001894 :
IPR018216 : Cathelicidin_CS.
IPR018216 :
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular component Extracellular region IEA
GO:0019835 Biological process Cytolysis IMP
GO:0050829 Biological process Defense response to Gram-negative bacterium IMP
GO:0050830 Biological process Defense response to Gram-positive bacterium IMP
GO:0005576 Cellular component Extracellular region IEA
GO:0008219 Biological process Cell death IMP
GO:0019835 Biological process Cytolysis IMP
GO:0050829 Biological process Defense response to Gram-negative bacterium IMP
GO:0050830 Biological process Defense response to Gram-positive bacterium IMP
GO:0005576 Biological process Extracellular region IEA
GO:0019835 Biological process Cytolysis IMP
GO:0050829 Biological process Defense response to Gram-negative bacterium IMP
GO:0050830 Biological process Defense response to Gram-positive bacterium IMP
GO:0005576 Biological process Extracellular region IEA
GO:0008219 Biological process Cell death IMP
GO:0019835 Biological process Cytolysis IMP
GO:0050829 Biological process Defense response to Gram-negative bacterium IMP
GO:0050830 Biological process Defense response to Gram-positive bacterium IMP
GO:0005576 Cellular component Extracellular region IEA
GO:0019835 Biological process Cytolysis IMP
GO:0050829 Biological process Defense response to Gram-negative bacterium IMP
GO:0050830 Biological process Defense response to Gram-positive bacterium IMP
GO:0005576 Cellular component Extracellular region IEA
GO:0008219 Biological process Cell death IMP
GO:0019835 Biological process Cytolysis IMP
GO:0050829 Biological process Defense response to Gram-negative bacterium IMP
GO:0050830 Biological process Defense response to Gram-positive bacterium IMP
Length : 28
Sequence:
RGLRRLGRKIAHGVKKYGPTVLRIIRIA

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