| CAMPSQ17554 |
| Title : |
NC4- Dermaseptin S4 |
| Source : |
Synthetic construct |
| UniProt: |
P80280 |
| PDB: |
2DD6 |
| Structure Database : |
CAMPST114 |
| PubMed : |
11847217,11937508,16436701,15917541,21741801,16870756 |
| Activity : |
Antibacterial, Antiparasitic |
| Gram Nature : |
Gram+, Gram- |
| Target : |
Escherichia coli TG1(IC50 = 1.35+-0.1 microM), Leishmania major (promastigote)(LC50 = 9+-3 microM), Plasmodium falciparum(IC50 = 5.3+-0.7 microM), Plasmodium falciparum(IC50 = 6.2+-0.5 microM), Escherichia coli K91BK(MIC = >100 microM), Escherichia coli K91BK(IC50 = >100 microM), Escherichia coli ATCC 25922(MIC = 1.5+-0 microM), Staphylococcus aureus ATCC 25923(MIC = 0.75+-0 microM), Leishmania major (promastigote)(LC = 3.12 microM) |
| Hemolytic Activity : |
Human erythrocytes (50% Hemolysis at >60 microM), Human erythrocytes (10% Hemolysis at 60 microM), Human erythrocytes (14% Hemolysis at 100 microM), Human erythrocytes (50% Hemolysis at >100 microM), Human erythrocytes (50% Hemolysis at 25+-3 microM), Human erythrocytes (50% Hemolysis at 6+-0.5 microM), Human erythrocytes (50% Hemolysis at 30+-2 microM), Human erythrocytes (50% Hemolysis at 18+-2 microM), Human erythrocytes (50% Hemolysis at 80 microM), Human erythrocytes (50% Hemolysis at 75 microM), Human erythrocytes (50% Hemolysis at 60 microM), Human erythrocytes (50% Hemolysis at 15 microM), Human erythrocytes (50% Hemolysis at 4.5 microM), Human erythrocytes (50% Hemolysis at 9 microM) |
| Validated : |
Experimentally validated |
| Gene Ontology : |
| GO ID |
Ontology |
Definition |
Evidence |
| GO:0005576 |
Cellular component |
Extracellular region |
IEA |
| GO:0042742 |
Biological process |
Defense response to bacterium |
IEA |
| GO:0050832 |
Biological process |
Defense response to fungus |
IEA |
| GO:0044179 |
Biological process |
Hemolysis in other organism |
IEA |
| GO:0005576 |
Cellular component |
Extracellular region |
IEA |
| GO:0042742 |
Biological process |
Defense response to bacterium |
IEA |
| GO:0050832 |
Biological process |
Defense response to fungus |
IEA |
| GO:0044179 |
Biological process |
Hemolysis in another organism |
IEA |
|
| Length : |
13 |
Sequence: |
ALWKTLLKKVLKA |