CAMPSQ15816
Title : Kininogen-1
Source : Rattus norvegicus [Rat]
Taxonomy : Animalia
UniProt: P08934
Activity : Antimicrobial
Validated : Predicted (Based on signature)
AMP Family : Cystatin
Signature :
ID Type Pattern / HMM
CathelicidinH_140 HMM
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Extracellular region IBA
GO:0005615 Extracellular space IDA
GO:0043231 Intracellular membrane-bounded organelle IDA
GO:0043204 Perikaryon IDA
GO:0004869 Cysteine-type endopeptidase inhibitor activity IDA
GO:0004866 Endopeptidase inhibitor activity IBA
GO:0002020 Protease binding IPI
GO:0005102 Signaling receptor binding ISO
GO:0007596 Blood coagulation IEA
GO:0002542 Factor XII activation IDA
GO:0006954 Inflammatory response IEP
GO:0030195 Negative regulation of blood coagulation ISO
GO:0007162 Negative regulation of cell adhesion ISO
GO:0010951 Negative regulation of endopeptidase activity IBA
GO:0050672 Negative regulation of lymphocyte proliferation IDA
GO:0043407 Negative regulation of MAP kinase activity IDA
GO:0045861 Negative regulation of proteolysis IDA
GO:0042130 Negative regulation of T cell proliferation IDA
GO:0007204 Positive regulation of cytosolic calcium ion concentration ISO
GO:0001938 Positive regulation of endothelial cell proliferation IDA
GO:0048146 Positive regulation of fibroblast proliferation IDA
GO:0043410 Positive regulation of MAPK cascade IDA
GO:0052548 Regulation of endopeptidase activity IDA
GO:0042311 Vasodilation IEA
Length : 639
Sequence:
 MKLITILLLCSRLLPSLAQEEDAQEMDCNDESLFQAVDTALKKYNAGLKSGNQFVLYQVT
EGTKKDGSKTFYSFKYQIKEGNCSVQSGFAWQDCDFKDAEEAATGECTATLEKRRNNKFS
IATQICNITPGKGPIVTNEYHCLGCMHPISVDSPELGPVLKHAVEHFNNNTKHTHLFALG
EVKSADRQVVAGMNYQIIYSIVQTNCSKEDFPSLHEDCVPLPSGDDGECKGNAFVDIHKT
IAGFSDSCEFYPGDDLFELLPEDCPGCPRNIPVDSPELKEALGHSIAQLNAENNHTFYFK
IDTVKKATSQVVAGTKYVIEFIARETKCSKESNAELTADCETKRLGQSLNCNANVYMRPW
ENKVVPTVKCKVLDMTSVIRRPPGFSPFRAPRVKKPKESTTVSPSYIARVQEERDPGNEQ
GPIHGHGWLHAKQIKNKNHQGHKHGHGIGHGHQKPHGLGHGHQLKLDDLKQQREDGYDHR
HPVGHGHGQRHGHGHGHGHGRDKHTNKDKNNVKHTDQRRAPLTSSSEDNTTSTQIQGRTE
GFTLNPPLAQPAVISRGFQDSGFTEGVIATTSPYDTETHDDLIPDIHVQPDSLSFKLISD
FPEATSHKCPGRPWKPVSRKDPTIETTEFSDFDLLDALS

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