CAMPSQ1142
Title : Melittin
Source : Apis mellifera [Honeybee]
Taxonomy : Animalia, Insects
UniProt: P01501
PDB: 1BH1, 2MLT
PubMed : 9568968, 35236909
Activity : Antibacterial, Antiviral
Gram Nature : Gram -ve
Target :
E. coli (1.5 microM) , HIV (0.9-1.5 microM), SARS CoV2 (EC50 = 0.656 microg)
Hemolytic Activity :
sheep red blood cells (11mM)
Validated : Experimentally validated
Pfam : PF01372 : Melittin ( Melittin )
InterPro : IPR002116 : Melittin/Api_allergen.
IPR002116 :
AMP Family : Melittin
Signature :
ID Type Pattern / HMM
MelittinH26_2 HMM
MelittinH_5 HMM
MelittinP26_2 Pattern G-I-G-A-V-L-K-V-L-[AT]-T-G-L-P-A-L-I-S-W-I-K-x(2)-[QR]-Q
MelittinP_5 Pattern G-L-P-[AT]-L-I-S-W-I-K
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular component Extracellular region IEA
GO:0046930 Cellular component Pore complex IEA
GO:0015288 Molecular function Porin activity IEA
GO:0004860 Molecular function Protein kinase inhibitor activity IEA
GO:0090729 Molecular function Toxin activity IEA
GO:0044179 Biological process Hemolysis in other organism IEA
GO:0006811 Biological process Ion transport IEA
GO:0005576 Cellular component Extracellular region IEA
GO:0046930 Cellular component Pore complex IEA
GO:0015288 Molecular function Porin activity IEA
GO:0004860 Molecular function Protein kinase inhibitor activity IEA
GO:0090729 Molecular function Toxin activity IEA
GO:0044179 Biological process Hemolysis in another organism IEA
GO:0006811 Biological process Ion transport IEA
GO:0044218 Cellular component Other organism cell membrane IEA
GO:0008289 Molecular function Lipid binding IDA
GO:0140678 Molecular function Molecular function inhibitor activity IEP
GO:0051179 Biological process Localization IDA
Length : 26
Sequence:
 GIGAVLKVLTTGLPALISWIKRKRQQ

| © 2022, Biomedical Informatics Centre, ICMR-NIRRCH |
ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Maharashtra, India