This family comprises of peptides isolated from leeches and Hydra. They contain a disulphide-stabilised ?-? motif. They possess a broad range of antimicrobial activity against Gram-negative and Gram-positive bacteria including multidrug-resistant strains via membrane permeabilization. Macins share high sequence identity including eight conserved cysteine residues [PMID: 22396551].
Note:
The format for Signature ID is the family name, followed by H or P for HMM or Pattern respectively. The integer suffixed to H or P denotes the length of the sequences used to create the family signature. If no integer is suffixed, it indicates that the signature was created using all the sequences of the family. The integer following the underscore denotes the number of sequences used for the creation of signatures.
For example:
AureinH_21 is a HMM for Aurein family created using 21 sequences.
AureinP16_9 is a pattern for Aurein family derived using 9 input sequences that are 16 residues long.
