Hepcidin

Description
Hepcidin is a antibacterial and anti-fungal protein expressed in the liver and is also a signalling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted beta-sheet with an unusual disulphide bond found at the turn of the hairpin [PMID: 12138110].
Pfam
Interpro
Patterns
HepcidinP20_4
 C-x-[FW]-C-C-x-C-C-x(4,5)-C
HepcidinP21_2
 C-R-F-C-C-[NR]-C-C-P-[NR]-M-[RS]-G-C-G-[IV]-C-C-R-F
HepcidinP24_2
 P-A-G-C-R-F-C-C-G-C-C-P-N-M-x-G-C-G-V-C-C-R-F
HepcidinP25_6
 C-x-[FWY]-C-C-x-C-C-x(4)-C-G-x-C-C-[KR]
HepcidinP31_2
 C-x(3)-C-x-[CP]-[CT]-x-D-x-V-x-C-G-[TV]-x-C-[DK]-F
HMMs
HepcidinH20_4
HepcidinH21_2
HepcidinH24_2
HepcidinH25_6
HepcidinH31_2
HepcidinH_22

Note:
The format for Signature ID is the family name, followed by H or P for HMM or Pattern respectively. The integer suffixed to H or P denotes the length of the sequences used to create the family signature. If no integer is suffixed, it indicates that the signature was created using all the sequences of the family. The integer following the underscore denotes the number of sequences used for the creation of signatures.

For example:
AureinH_21 is a HMM for Aurein family created using 21 sequences.
AureinP16_9 is a pattern for Aurein family derived using 9 input sequences that are 16 residues long.

| © 2022, Biomedical Informatics Centre, ICMR-NIRRCH |
ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Maharashtra, India