CAMPSQ846
Title : Calcitermin
GenInfo Identifier : 2507565
Source : Homo sapiens [Human]
Taxonomy : Animalia, Mammals
UniProt: P80511
PDB: 1E8A, 1GQM, 1ODB, 2WC8, 2WCB, 2WCE, 2WCF
Structure Database : CAMPST389, CAMPST633, CAMPST534, CAMPST578, CAMPST579, CAMPST580, CAMPST581
PubMed : 11522286
Activity : Antibacterial, Antifungal
Gram Nature : Gram -ve
Target :
E.coli , P.aruginosa , C. albicans at pH5.4
Validated : Experimentally validated
Comment : Inactive against L.monocytogenes , S.aureus
Pfam : PF01023 : S_100 ( S-100/ICaBP type calcium binding domain )
InterPro : IPR011992 : EF-hand-like_dom.
IPR002048 : EF_hand_dom.
IPR001751 : S100/CaBP-9k_CS.
IPR013787 : S100_Ca-bd_sub.
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005737 Cellular component Cytoplasm IDA
GO:0005856 Cellular component Cytoskeleton TAS
GO:0005829 Cellular component Cytosol TAS
GO:0005576 Cellular component Extracellular region TAS
GO:0005615 Cellular component Extracellular space IBA
GO:0005634 Cellular component Nucleus IDA
GO:0005886 Cellular component Plasma membrane TAS
GO:0034774 Cellular component Secretory granule lumen TAS
GO:0005509 Molecular function Calcium ion binding IBA
GO:0048306 Molecular function Calcium-dependent protein binding IBA
GO:0005507 Molecular function Copper ion binding TAS
GO:0050786 Molecular function RAGE receptor binding IDA
GO:0008270 Molecular function Zinc ion binding TAS
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IDA
GO:0042742 Biological process Defense response to bacterium TAS
GO:0050832 Biological process Defense response to fungus IDA
GO:0006954 Biological process Inflammatory response TAS
GO:0045087 Biological process Innate immune response TAS
GO:0031640 Biological process Killing of cells of other organism IDA
GO:0045576 Biological process Mast cell activation TAS
GO:0002548 Biological process Monocyte chemotaxis TAS
GO:0030593 Biological process Neutrophil chemotaxis TAS
GO:0043123 Biological process Positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
GO:0050729 Biological process Positive regulation of inflammatory response TAS
GO:0043406 Biological process Positive regulation of MAP kinase activity TAS
GO:0051092 Biological process Positive regulation of NF-kappaB transcription factor activity TAS
GO:0006805 Biological process Xenobiotic metabolic process IDA
GO:0005737 Cellular component Cytoplasm IDA
GO:0005856 Cellular component Cytoskeleton TAS
GO:0005829 Cellular component Cytosol TAS
GO:0005576 Cellular component Extracellular region TAS
GO:0005615 Cellular component Extracellular space IBA
GO:0005634 Cellular component Nucleus IDA
GO:0005886 Cellular component Plasma membrane TAS
GO:0034774 Cellular component Secretory granule lumen TAS
GO:0005509 Molecular function Calcium ion binding IBA
GO:0048306 Molecular function Calcium-dependent protein binding IBA
GO:0005507 Molecular function Copper ion binding TAS
GO:0042802 Molecular function Identical protein binding IPI
GO:0050786 Molecular function RAGE receptor binding IDA
GO:0008270 Molecular function Zinc ion binding TAS
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IDA
GO:0042742 Biological process Defense response to bacterium TAS
GO:0050832 Biological process Defense response to fungus IDA
GO:0006954 Biological process Inflammatory response TAS
GO:0045087 Biological process Innate immune response TAS
GO:0031640 Biological process Killing of cells of another organism IDA
GO:0045576 Biological process Mast cell activation TAS
GO:0002548 Biological process Monocyte chemotaxis TAS
GO:0030593 Biological process Neutrophil chemotaxis TAS
GO:0043123 Biological process Positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
GO:0050729 Biological process Positive regulation of inflammatory response TAS
GO:0043406 Biological process Positive regulation of MAP kinase activity TAS
GO:0051092 Biological process Positive regulation of NF-kappaB transcription factor activity TAS
GO:0006805 Biological process Xenobiotic metabolic process IDA
Length : 15
Sequence:
 VAIALKAAHYHTHKE

| © 2022, Biomedical Informatics Centre, ICMR-NIRRCH |
ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Maharashtra, India