CAMPSQ755
Title : Human Alpha-Defensin-6
GenInfo Identifier : 109156999
Source : Homo sapiens [Human]
Taxonomy : Animalia, Mammals
UniProt: Q01524
PDB: 1ZMQ, 3QTE
Structure Database : CAMPST97, CAMPST296
PubMed : 17088326
Activity : Antibacterial
Gram Nature : Gram +ve
Target :
E. faecium ATCC 1438 ( IC50 = 5.6 +/- 4.0 microg/ml )
Validated : Experimentally validated
Comment : Inactive against E. coli ( IC50 > 100 microg/ml ) , S. aureus ( IC50 > 100 microg/ml ) , C. albicans ATCC 99788 amphotericin B-resistant ( IC90 > 100 microg/ml ) , P. aeruginosa PA01 ( IC50 > 100 microg/ml)
Pfam : PF00323 : Defensin_1 ( Mammalian defensin )
PF00879 : Defensin_propep ( Defensin propeptide )
InterPro : IPR016327 : Alpha-defensin.
IPR006080 : Defensin_beta/neutrophil.
IPR002366 : Defensin_propep.
IPR006081 : Mammalian_defensins.
AMP Family : Defensin
Signature :
ID Type Pattern / HMM
DefensinH32_11 HMM
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular component Extracellular region TAS
GO:0005615 Cellular component Extracellular space IBA
GO:0005796 Cellular component Golgi lumen TAS
GO:0042803 Molecular function Protein homodimerization activity IDA
GO:0019731 Biological process Antibacterial humoral response IBA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IBA
GO:0071222 Biological process Cellular response to lipopolysaccharide IBA
GO:0050832 Biological process Defense response to fungus IEA
GO:0050829 Biological process Defense response to Gram-negative bacterium IBA
GO:0050830 Biological process Defense response to Gram-positive bacterium IBA
GO:0002227 Biological process Innate immune response in mucosa IBA
GO:0031640 Biological process Killing of cells of other organism IDA
GO:0051673 Biological process Membrane disruption in other organism IBA
GO:0005576 Cellular component Extracellular region TAS
GO:0005615 Cellular component Extracellular space IBA
GO:0005796 Cellular component Golgi lumen TAS
GO:0030133 Cellular component Transport vesicle IEA
GO:0042803 Molecular function Protein homodimerization activity IDA
GO:0019731 Biological process Antibacterial humoral response IBA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IBA
GO:0071222 Biological process Cellular response to lipopolysaccharide IBA
GO:0050832 Biological process Defense response to fungus IEA
GO:0050829 Biological process Defense response to Gram-negative bacterium IBA
GO:0050830 Biological process Defense response to Gram-positive bacterium IBA
GO:0002227 Biological process Innate immune response in mucosa IBA
GO:0031640 Biological process Killing of cells of another organism IDA
GO:0051673 Biological process Membrane disruption in another organism IBA
Length : 32
Sequence:
 AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL

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