| CAMPSQ739 |
| Title : |
LEAP-2 |
| GenInfo Identifier : |
20138667 |
| Source : |
Homo sapiens [Human] |
| Taxonomy : |
Animalia, Mammals |
| UniProt: |
Q969E1 |
| PDB: |
2L1Q |
| Structure Database : |
CAMPST188 |
| PubMed : |
12493837 |
| Activity : |
Antibacterial |
| Target : |
Bacillus megaterium ATCC14581, Bacillus subtilis ATCC6051, Micrococcus luteus ATCC9341, Staphylococcus carnosus DSM20501, Neisseria cinerea ATCC14685 , Saccharomyces cerevisiae ATCC9763 , Rhodotorula muciloginosa DSM70403 |
| Validated : |
Experimentally validated |
| Comment : |
Inactive against Escherichia coli BL21 , Pseudomonas fluorescens |
| Pfam : |
PF07359 : LEAP-2 ( Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) )
|
| InterPro : |
IPR009955 : LEAP-2.
|
| AMP Family : |
LEAP-2 |
| Signature : |
| ID |
Type |
Pattern / HMM |
|
LEAP-2H_6 |
HMM |
 |
|
LEAP-2P_6 |
Pattern |
W-R-x-[IMV]-[GNST]-x-[KR]-P-x-G-A-x-C-[QR]-x(3)-E-C-x-T-x(2)-C-[KR]-x(3)-C-x(2)-[NRS] |
|
| Gene Ontology : |
| GO ID |
Ontology |
Definition |
Evidence |
| GO:0005576 |
Cellular component |
Extracellular region |
TAS |
| GO:0061844 |
Biological process |
Antimicrobial humoral immune response mediated by antimicrobial peptide |
IMP |
| GO:0042742 |
Biological process |
Defense response to bacterium |
IEA |
| GO:0050832 |
Biological process |
Defense response to fungus |
IMP |
|
| Length : |
40 |
Sequence: |
MTPFWRGVSLRPIGASCRDDSECITRLCRKRRCSLSVAQE |
