CAMPSQ730
Title : Human Defensin-5
GenInfo Identifier : 109156995
Source : Homo sapiens [Human]
Taxonomy : Animalia, Mammals
UniProt: Q01523
PDB: 1ZMP, 3I5W, 4E82, 4E83, 4E86
Structure Database : CAMPST96, CAMPST659, CAMPST316, CAMPST317, CAMPST318
PubMed : 18191790 , 17088326, 30808760
Activity : Antibacterial, Antifungal, Antiviral
Gram Nature : Gram +ve, Gram -ve
Target :
E. coli ATCC 25922 ( IC99 = 49.5 +/- 0.2 microg/ml) , S. aureus ATCC 29123 ( IC99 = 6.3 +/- 1.8 microg/ml) , C. albicans ATCC 99788 amphotericin B resistant ( IC90 > 100 microg/ml ) , Adenovirus, Refer PubMed ID: A. baumannii 4-MRGN, K. pneumoniae 4-MRGN, P. aeruginosa ATCC27853, E. faecium 475747, B. longum, L. fermentum, L. salivarius, S. salivarius salivarius, Akkermansia muciniphila, B. subtilis 168trpC, S. aureus USA300, B. adolescentis Ni3.29c, B. breve, B. vulgatus DSM1447, L. rhamnosus, E. coli MC1000
Validated : Experimentally validated
Pfam : PF00323 : Defensin_1 ( Mammalian defensin )
PF00879 : Defensin_propep ( Defensin propeptide )
InterPro : IPR016327 : Alpha-defensin.
IPR006080 : Defensin_beta/neutrophil.
IPR002366 : Defensin_propep.
IPR006081 : Mammalian_defensins.
AMP Family : Defensin
Signature :
ID Type Pattern / HMM
DefensinH33_12 HMM
DefensinH32_11 HMM
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular component Extracellular region TAS
GO:0005615 Cellular component Extracellular space IBA
GO:0005796 Cellular component Golgi lumen TAS
GO:0043231 Cellular component Intracellular membrane-bounded organelle IDA
GO:0030496 Cellular component Midbody IDA
GO:0034774 Cellular component Secretory granule lumen TAS
GO:0030133 Cellular component Transport vesicle IEA
GO:0042803 Molecular function Protein homodimerization activity IDA
GO:0019731 Biological process Antibacterial humoral response IBA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IBA
GO:0071222 Biological process Cellular response to lipopolysaccharide IBA
GO:0050832 Biological process Defense response to fungus IEA
GO:0050829 Biological process Defense response to Gram-negative bacterium IMP
GO:0050830 Biological process Defense response to Gram-positive bacterium IMP
GO:0045087 Biological process Innate immune response IMP
GO:0002227 Biological process Innate immune response in mucosa IBA
GO:0051873 Biological process Killing by host of symbiont cells IDA
GO:0031640 Biological process Killing of cells of other organism IDA
GO:0051673 Biological process Membrane disruption in other organism IBA
GO:1905710 Biological process Positive regulation of membrane permeability IMP
GO:0005576 Cellular component Extracellular region TAS
GO:0005615 Cellular component Extracellular space IDA
GO:0005796 Cellular component Golgi lumen TAS
GO:0043231 Cellular component Intracellular membrane-bounded organelle IDA
GO:0030496 Cellular component Midbody IDA
GO:0030141 Cellular component Secretory granule IDA
GO:0034774 Cellular component Secretory granule lumen TAS
GO:0030133 Cellular component Transport vesicle IEA
GO:0042803 Molecular function Protein homodimerization activity IDA
GO:0019731 Biological process Antibacterial humoral response IBA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IDA
GO:0071222 Biological process Cellular response to lipopolysaccharide IBA
GO:0050832 Biological process Defense response to fungus IEA
GO:0050829 Biological process Defense response to Gram-negative bacterium IDA
GO:0050830 Biological process Defense response to Gram-positive bacterium IDA
GO:0045087 Biological process Innate immune response IMP
GO:0002227 Biological process Innate immune response in mucosa IBA
GO:0051873 Biological process Killing by host of symbiont cells IDA
GO:0031640 Biological process Killing of cells of another organism IDA
GO:0051673 Biological process Membrane disruption in another organism IDA
GO:0032757 Biological process Positive regulation of interleukin-8 production IDA
GO:0051289 Biological process Protein homotetramerization IDA
Length : 32
Sequence:
 ATCYCRTGRCATRESLSGVCEISGRLYRLCCR

| © 2022, Biomedical Informatics Centre, ICMR-NIRRCH |
ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai-400012
Maharashtra, India