| CAMPSQ56 |
| Title : |
Cecropin-A |
| GenInfo Identifier : |
116087, 223330 |
| Source : |
Hyalophora cecropia [Cecropia moth] |
| Taxonomy : |
Animalia, Insects |
| UniProt: |
P01507 |
| PDB: |
1D9J, 1D9L, 1D9M, 1D9O, 1D9P, 1F0D, 1F0E, 1F0F, 1F0G, 1F0H |
| Structure Database : |
CAMPST10, CAMPST490, CAMPST491, CAMPST492, CAMPST493, CAMPST15, CAMPST16, CAMPST17, CAMPST18, CAMPST19 |
| PubMed : |
7140755, 27367675 |
| Activity : |
Antibacterial |
| Gram Nature : |
Gram +ve, Gram -ve |
| Target : |
E. coli D21 ( LC = 0.19 microM) , E. coli D31 ( LC = 0.21 microM) , Serratia marcescens Db11 ( LC = 4.2 microM) , Serratia marcescens Db1108 ( LC = 2.5 microM) , Serratia marcescens Db1121 ( LC = 4.4 microM) , Serratia marcescens Strain 122 ( LC = 3.2 microM) , P. aeruginosa OT97 ( LC = 4.8 microM ) , Xenorhabdus nematophilus Xn21 ( LC = 1.4 microM) , Bacillus megaterium Bmll ( LC = 0.70 microM) , B. subtilis Bs11 ( LC = 61 microM) , B. thuringiensis Bt11 ( MIC > 80 microM) , Streptococcus fecalis AD-4 ( LC = 15 microM) , Streptococcus fecalis DS16 ( LC = 74 microM) , Micrococcus luteus M111 ( LC = 4.6 microM) [Refer PubMed ID: 27367675 ]E.coli K88 (MIC = 64 ± 0.72 microg/ml), E.coli CVCC245 (MIC = 4 ± 0.28 microg/ml), S.aureus CVCC 26003 (MIC = 128 ± 7.57 microg/ml), S.aureus ATCC 25923 (MIC = 198 ± 10.1 microg/ml), Listeria monocytogene CVCC 1599 (MIC = 64 ± 2.99 microg/ml), Micrococcus luteus CVCC 28001 (MIC = 154 ± 5.49 microg/ml) |
| Hemolytic Activity : |
Sheep RBC (HC50 = 169 ± 15.1 microg/ml) |
| Validated : |
Experimentally validated |
| Pfam : |
PF00272 : Cecropin ( Cecropin family )
|
| InterPro : |
IPR000875 : Cecropin.
|
| AMP Family : |
Cecropin |
| Signature : |
| ID |
Type |
Pattern / HMM |
|
CecropinH37_9 |
HMM |
 |
|
CecropinH_72 |
HMM |
|
|
| Gene Ontology : |
| GO ID |
Ontology |
Definition |
Evidence |
| GO:0005576 |
Cellular component |
Extracellular region |
IEA |
| GO:0019731 |
Biological process |
Antibacterial humoral response |
IEA |
| GO:0045087 |
Biological process |
Innate immune response |
IEA |
| GO:0005576 |
Cellular component |
Extracellular region |
IEA |
| GO:0019731 |
Biological process |
Antibacterial humoral response |
IEA |
| GO:0050830 |
Biological process |
Defense response to Gram-positive bacterium |
IEA |
| GO:0045087 |
Biological process |
Innate immune response |
IEA |
|
| Length : |
37 |
Sequence: |
KWKLFKKIEKVGQNIRDGIIKAGPAVAVVGQATQIAK |
