CAMPSQ3834
Title : Human islet amyloid polypeptide
Source : Homo sapiens [Human]
Taxonomy : Animalia, Mammals
UniProt: P10997
PDB: 2L86
Structure Database : CAMPST680
PubMed : 22944668
Activity : Antimicrobial
Validated : Experimentally validated
Pfam : PF00214 : Calc_CGRP_IAPP ( Calcitonin / CGRP / IAPP family )
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular component Extracellular region TAS
GO:0005615 Cellular component Extracellular space IBA
GO:0016234 Cellular component Inclusion body IDA
GO:0001540 Molecular function Amyloid-beta binding TAS
GO:0005179 Molecular function Hormone activity IEA
GO:0042802 Molecular function Identical protein binding IDA
GO:0005102 Molecular function Signaling receptor binding TAS
GO:0007189 Biological process Adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
GO:0097647 Biological process Amylin receptor signaling pathway IGI
GO:1990000 Biological process Amyloid fibril formation IDA
GO:0006915 Biological process Apoptotic process TAS
GO:0007267 Biological process Cell-cell signaling TAS
GO:0042755 Biological process Eating behavior IEA
GO:1905907 Biological process Negative regulation of amyloid fibril formation TAS
GO:0045779 Biological process Negative regulation of bone resorption IEA
GO:0045596 Biological process Negative regulation of cell differentiation IEA
GO:0008285 Biological process Negative regulation of cell population proliferation IDA
GO:0010823 Biological process Negative regulation of mitochondrion organization TAS
GO:0031333 Biological process Negative regulation of protein-containing complex assembly TAS
GO:0043065 Biological process Positive regulation of apoptotic process TAS
GO:1905665 Biological process Positive regulation of calcium ion import across plasma membrane IGI
GO:0010942 Biological process Positive regulation of cell death IGI
GO:0007204 Biological process Positive regulation of cytosolic calcium ion concentration NAS
GO:0070374 Biological process Positive regulation of ERK1 and ERK2 cascade IGI
GO:0010628 Biological process Positive regulation of gene expression IGI
GO:0043410 Biological process Positive regulation of MAPK cascade NAS
GO:0033138 Biological process Positive regulation of peptidyl-serine phosphorylation IGI
GO:0010739 Biological process Positive regulation of protein kinase A signaling IGI
GO:0051897 Biological process Positive regulation of protein kinase B signaling IGI
GO:0031648 Biological process Protein destabilization IDA
GO:0051260 Biological process Protein homooligomerization IDA
GO:0019233 Biological process Sensory perception of pain IEA
GO:0007165 Biological process Signal transduction TAS
Length : 37
Sequence:
 KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY

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