CAMPSQ3752
Title : CCL21
Source : Homo sapiens [Human]
Taxonomy : Animalia, Mammals
UniProt: O00585
PDB: 2L4N
Structure Database : CAMPST627
PubMed : 12949249
Activity : Antibacterial
Gram Nature : Gram +ve, Gram -ve
Target :
Escherichia coli ATCC25922, Staphylococcus aureus ATCC29213
Validated : Experimentally validated
Pfam : PF00048 : IL8 ( Small cytokines (intecrine/chemokine), interleukin-8 like )
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular component Extracellular region TAS
GO:0005615 Cellular component Extracellular space IBA
GO:0048020 Molecular function CCR chemokine receptor binding IBA
GO:0031732 Molecular function CCR7 chemokine receptor binding ISS
GO:0008009 Molecular function Chemokine activity IDA
GO:0042379 Molecular function Chemokine receptor binding IDA
GO:0090630 Biological process Activation of GTPase activity IDA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IDA
GO:0060326 Biological process Cell chemotaxis IDA
GO:0048469 Biological process Cell maturation ISS
GO:0007267 Biological process Cell-cell signaling TAS
GO:1990869 Biological process Cellular response to chemokine ISS
GO:0071346 Biological process Cellular response to interferon-gamma IBA
GO:0071347 Biological process Cellular response to interleukin-1 IBA
GO:0071356 Biological process Cellular response to tumor necrosis factor IBA
GO:0038116 Biological process Chemokine (C-C motif) ligand 21 signaling pathway ISS
GO:0070098 Biological process Chemokine-mediated signaling pathway IBA
GO:0002407 Biological process Dendritic cell chemotaxis IDA
GO:0097026 Biological process Dendritic cell dendrite assembly ISS
GO:0048245 Biological process Eosinophil chemotaxis IBA
GO:0001768 Biological process Establishment of T cell polarity IDA
GO:0007186 Biological process G protein-coupled receptor signaling pathway IDA
GO:0006955 Biological process Immune response TAS
GO:0001771 Biological process Immunological synapse formation ISS
GO:0006954 Biological process Inflammatory response IBA
GO:0031640 Biological process Killing of cells of other organism IDA
GO:0048247 Biological process Lymphocyte chemotaxis IBA
GO:0035759 Biological process Mesangial cell-matrix adhesion IDA
GO:0002548 Biological process Monocyte chemotaxis IBA
GO:2000669 Biological process Negative regulation of dendritic cell apoptotic process IDA
GO:2000548 Biological process Negative regulation of dendritic cell dendrite assembly ISS
GO:1903237 Biological process Negative regulation of leukocyte tethering or rolling IDA
GO:0030593 Biological process Neutrophil chemotaxis IBA
GO:0030838 Biological process Positive regulation of actin filament polymerization IDA
GO:0033630 Biological process Positive regulation of cell adhesion mediated by integrin IDA
GO:2000147 Biological process Positive regulation of cell motility IDA
GO:0001954 Biological process Positive regulation of cell-matrix adhesion IDA
GO:0050921 Biological process Positive regulation of chemotaxis ISS
GO:0002606 Biological process Positive regulation of dendritic cell antigen processing and presentation ISS
GO:0070374 Biological process Positive regulation of ERK1 and ERK2 cascade IDA
GO:0051491 Biological process Positive regulation of filopodium assembly IDA
GO:0010560 Biological process Positive regulation of glycoprotein biosynthetic process ISS
GO:0043547 Biological process Positive regulation of GTPase activity IBA
GO:0043123 Biological process Positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
GO:0046330 Biological process Positive regulation of JNK cascade IDA
GO:2000529 Biological process Positive regulation of myeloid dendritic cell chemotaxis IDA
GO:0090023 Biological process Positive regulation of neutrophil chemotaxis IDA
GO:0043552 Biological process Positive regulation of phosphatidylinositol 3-kinase activity IDA
GO:0045860 Biological process Positive regulation of protein kinase activity IDA
GO:0051897 Biological process Positive regulation of protein kinase B signaling IDA
GO:0031274 Biological process Positive regulation of pseudopodium assembly IDA
GO:0048260 Biological process Positive regulation of receptor-mediated endocytosis ISS
GO:0010820 Biological process Positive regulation of T cell chemotaxis ISS
GO:2000406 Biological process Positive regulation of T cell migration IDA
GO:0051209 Biological process Release of sequestered calcium ion into cytosol IDA
GO:0034695 Biological process Response to prostaglandin E IDA
GO:0031529 Biological process Ruffle organization IDA
GO:0031295 Biological process T cell costimulation ISS
Length : 111
Sequence:
 SDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWV
QQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP

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