CAMPSQ3743
Title : XCL1
Source : Homo sapiens [Human]
Taxonomy : Animalia, Mammals
UniProt: P47992
PDB: 2JP1
Structure Database : CAMPST621
PubMed : 12949249
Activity : Antibacterial
Gram Nature : Gram +ve, Gram -ve
Target :
Escherichia coli ATCC25922, Staphylococcus aureus ATCC29213
Validated : Experimentally validated
Pfam : PF00048 : IL8 ( Small cytokines (intecrine/chemokine), interleukin-8 like )
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular component Extracellular region TAS
GO:0005615 Cellular component Extracellular space ISS
GO:0048020 Molecular function CCR chemokine receptor binding IBA
GO:0008009 Molecular function Chemokine activity IDA
GO:0042379 Molecular function Chemokine receptor binding IDA
GO:0042803 Molecular function Protein homodimerization activity IDA
GO:0061844 Biological process Antimicrobial humoral immune response mediated by antimicrobial peptide IDA
GO:0007267 Biological process Cell-cell signaling IDA
GO:0071346 Biological process Cellular response to interferon-gamma IBA
GO:0071347 Biological process Cellular response to interleukin-1 IBA
GO:0071353 Biological process Cellular response to interleukin-4 ISS
GO:0071560 Biological process Cellular response to transforming growth factor beta stimulus ISS
GO:0071356 Biological process Cellular response to tumor necrosis factor IBA
GO:0070098 Biological process Chemokine-mediated signaling pathway IBA
GO:0007186 Biological process G protein-coupled receptor signaling pathway IBA
GO:0006954 Biological process Inflammatory response IBA
GO:0031640 Biological process Killing of cells of other organism IDA
GO:0048247 Biological process Lymphocyte chemotaxis IBA
GO:0035782 Biological process Mature natural killer cell chemotaxis IDA
GO:0002548 Biological process Monocyte chemotaxis IBA
GO:2000562 Biological process Negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
GO:0043433 Biological process Negative regulation of DNA-binding transcription factor activity IDA
GO:0032689 Biological process Negative regulation of interferon-gamma production IDA
GO:0032703 Biological process Negative regulation of interleukin-2 production IDA
GO:0002725 Biological process Negative regulation of T cell cytokine production IDA
GO:2000518 Biological process Negative regulation of T-helper 1 cell activation IDA
GO:0002826 Biological process Negative regulation of T-helper 1 type immune response IC
GO:0045892 Biological process Negative regulation of transcription, DNA-templated IDA
GO:0030593 Biological process Neutrophil chemotaxis IBA
GO:2000538 Biological process Positive regulation of B cell chemotaxis ISS
GO:2000563 Biological process Positive regulation of CD4-positive, alpha-beta T cell proliferation ISS
GO:2000566 Biological process Positive regulation of CD8-positive, alpha-beta T cell proliferation IDA
GO:0070374 Biological process Positive regulation of ERK1 and ERK2 cascade IBA
GO:2000513 Biological process Positive regulation of granzyme A production IDA
GO:0071663 Biological process Positive regulation of granzyme B production IDA
GO:0043547 Biological process Positive regulation of GTPase activity IBA
GO:2000558 Biological process Positive regulation of immunoglobulin production in mucosal tissue ISS
GO:0032733 Biological process Positive regulation of interleukin-10 production IDA
GO:0002690 Biological process Positive regulation of leukocyte chemotaxis ISS
GO:2000503 Biological process Positive regulation of natural killer cell chemotaxis IDA
GO:0090023 Biological process Positive regulation of neutrophil chemotaxis ISS
GO:0051281 Biological process Positive regulation of release of sequestered calcium ion into cytosol IDA
GO:0010820 Biological process Positive regulation of T cell chemotaxis IDA
GO:0002726 Biological process Positive regulation of T cell cytokine production ISS
GO:0001916 Biological process Positive regulation of T cell mediated cytotoxicity IDA
GO:2000556 Biological process Positive regulation of T-helper 1 cell cytokine production ISS
GO:2000553 Biological process Positive regulation of T-helper 2 cell cytokine production ISS
GO:2000412 Biological process Positive regulation of thymocyte migration ISS
GO:0071636 Biological process Positive regulation of transforming growth factor beta production IDA
GO:0050727 Biological process Regulation of inflammatory response IDA
GO:0051209 Biological process Release of sequestered calcium ion into cytosol ISS
GO:0009615 Biological process Response to virus IDA
GO:0007165 Biological process Signal transduction IC
Length : 93
Sequence:
 VGSEVSDKRTCVSLTTQRLPVSRIKTYTITEGSLRAVIFITKRGLKVCADPQATWVRDVV
RSMDRKSNTRNNMIQTKPTGTQQSTNTAVTLTG

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