CAMPSQ3732 |
Title : |
RNase 7 |
Source : |
Homo sapiens [Human] |
Taxonomy : |
Animalia, Mammals |
UniProt: |
Q9H1E1 |
PDB: |
2HKY |
Structure Database : |
CAMPST565 |
PubMed : |
12244054 |
Activity : |
Antibacterial, Antifungal |
Gram Nature : |
Gram +ve, Gram -ve |
Target : |
Staphylococcus aureus, Propionibacterium acnes, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Vancomycin-resistant Enterococcus faecium (LD90 < 0.03 microM ) |
Validated : |
Experimentally validated |
Pfam : |
PF00074 : RnaseA ( Pancreatic ribonuclease )
|
InterPro : |
IPR001427 : RNaseA.
IPR023411 : RNaseA_AS.
IPR023412 : RNaseA_domain.
|
Gene Ontology : |
GO ID |
Ontology |
Definition |
Evidence |
GO:0005737 |
Cellular component |
Cytoplasm |
IDA |
GO:0005576 |
Cellular component |
Extracellular region |
IDA |
GO:0005615 |
Cellular component |
Extracellular space |
IDA |
GO:0004519 |
Molecular function |
Endonuclease activity |
IEA |
GO:0001530 |
Molecular function |
Lipopolysaccharide binding |
IDA |
GO:0003676 |
Molecular function |
Nucleic acid binding |
IEA |
GO:0042834 |
Molecular function |
Peptidoglycan binding |
IDA |
GO:0004540 |
Molecular function |
Ribonuclease activity |
IDA |
GO:0019731 |
Biological process |
Antibacterial humoral response |
IDA |
GO:0061844 |
Biological process |
Antimicrobial humoral immune response mediated by antimicrobial peptide |
IDA |
GO:0050832 |
Biological process |
Defense response to fungus |
IDA |
GO:0050829 |
Biological process |
Defense response to Gram-negative bacterium |
IDA |
GO:0050830 |
Biological process |
Defense response to Gram-positive bacterium |
IDA |
GO:0045087 |
Biological process |
Innate immune response |
IDA |
GO:0051673 |
Biological process |
Membrane disruption in other organism |
IDA |
GO:0005737 |
Cellular component |
Cytoplasm |
IDA |
GO:0005576 |
Cellular component |
Extracellular region |
IDA |
GO:0005615 |
Cellular component |
Extracellular space |
IDA |
GO:0004519 |
Molecular function |
Endonuclease activity |
IEA |
GO:0001530 |
Molecular function |
Lipopolysaccharide binding |
IDA |
GO:0003676 |
Molecular function |
Nucleic acid binding |
IEA |
GO:0042834 |
Molecular function |
Peptidoglycan binding |
IDA |
GO:0004540 |
Molecular function |
Ribonuclease activity |
IDA |
GO:0019731 |
Biological process |
Antibacterial humoral response |
IDA |
GO:0061844 |
Biological process |
Antimicrobial humoral immune response mediated by antimicrobial peptide |
IDA |
GO:0050832 |
Biological process |
Defense response to fungus |
IDA |
GO:0050829 |
Biological process |
Defense response to Gram-negative bacterium |
IDA |
GO:0050830 |
Biological process |
Defense response to Gram-positive bacterium |
IDA |
GO:0045087 |
Biological process |
Innate immune response |
IDA |
GO:0051673 |
Biological process |
Membrane disruption in another organism |
IDA |
|
Length : |
128 |
Sequence: |
KPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKI ACKNGDKNCHQSHGAVSLTMCKLTSGKYPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLV PVHLDRVL |