CAMPSQ3118
Title : Ascaphin-8
Source : Ascaphus truei [Coastal tailed frog]
Taxonomy : Animalia, Amphibia
UniProt: P0CJ32
PubMed : 15207717, 33932712, 23094651
Activity : Antibacterial, Antifungal
Gram Nature : Gram +ve, Gram -ve
Target :
Escherichia coli ( MIC = 6 microM ), Staphylococcus aureus ( MIC = 6 microM ), Pseudomonas aeruginosa ( MIC = 50 microM ), Enterobacter cloacae ( MIC = 13 microM ), Klebsiella pneumoniae ( MIC = 25 microM ), Proteus mirabilis ( MIC > 100 microM ), S. epidermidis ( MIC =25 microM ), E. faecalis ( MIC > 100 microM ), Streptococcus Group B ( MIC = 13 microM ), C. albicans ( MIC = 100 microM ); Refer PubMed ID 23094651 :- E. coli ATCC25922 (MIC= 3 microM), S. aureus ATCC25923 (MIC= 3 microM), E. coli ML35p (MIC= 1.6 microM), Pseudomonas aeruginosa ATCC 27853 (MIC= 3 microM), S. aureus multiresistant ATCCBAA-44 (MIC= 3 microM), Enterococcus faecalis ATCC 29212 (MIC= 12.5 microM); Refer PubMed ID 33932712:- A549 (IC50= 33.79 microM), C4-2B (IC50= 42.91 microM), HEK293T (IC50= 53.67 microM)
Hemolytic Activity :
Human erythrocytes ( HC50 = 50 microM ); Refer PubMed ID 23094651: Rat RBCs [HC50 = 115 microM], PubMed ID 33932712: Rabbit RBC [HC50 = >100 miroM]
Validated : Experimentally validated
AMP Family : Ascaphin
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular component Extracellular region IDA
GO:0050829 Biological process Defense response to Gram-negative bacterium IDA
GO:0050830 Biological process Defense response to Gram-positive bacterium IDA
GO:0044179 Biological process Hemolysis in other organism IDA
GO:0005576 Cellular component Extracellular region IDA
GO:0050829 Biological process Defense response to Gram-negative bacterium IDA
GO:0050830 Biological process Defense response to Gram-positive bacterium IDA
GO:0044179 Biological process Hemolysis in another organism IDA
Length : 19
Sequence:
 GFKDLLKGAAKALVKTVLF

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