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| CAMPSQ170 | ||||||||||
| Title : | Tritrpticin | |||||||||
| GenInfo Identifier : | 157872589 | |||||||||
| Source : | Sus scrofa [pig] | |||||||||
| Taxonomy : | Animalia, Mammals | |||||||||
| PDB: | 1D6X | |||||||||
| Structure Database : | CAMPST9 | |||||||||
| PubMed : | 8706838, 16563706, 12681513 | |||||||||
| Activity : | Antibacterial, Antifungal | |||||||||
| Gram Nature : | Gram +ve, Gram -ve | |||||||||
| Target : | [Refer PubMed ID - 8706838: Aspergillus fumigatus (MIC = 250 microg/ml), Candida albicans (MIC = 1000 microg/ml), E. coli DH5, P. aeruginosa, K. pneumoniae, S. epidermis, P. mirabilis, Streptococcus Group D]; [Refer PubMed ID - 16563706 (MIC of peptide with C terminal CO2H): Escherichia coli (MIC=32microg/ml), Salmonella typhimurium (MIC=32microg/ml), Bacillus subtilis (MIC=8microg/ml), Staphylococcus aureus (MIC=16microg/ml), MRSA, methicillin-resistant Staphylococcus aureus 1 (MIC=32microg/ml), VRE, vancomycin resistant Enterococcus faecium 1 (MIC=32microg/ml), MRSA 2 (MIC=64microg/ml), VRE2 (MIC=32microg/ml); (MIC of peptide with C terminal NH2) Escherichia coli (MIC=16microg/ml), Salmonella typhimurium (MIC=16microg/ml), Bacillus subtilis (MIC=4microg/ml), Staphylococcus aureus (MIC=8microg/ml)]; [ Refer PubMed ID - 12681513: E. coli (MIC = 32microg/ml), S. typhimurium (MIC = 32microg/ml), P. aeruginosa (MIC = 32microg/ml), B. subtilis (MIC = 8microg/ml), S. aureus (MIC = 16microg/ml), S. epidermidis (MIC = 8microg/ml)] |
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| Hemolytic Activity : | C terminal: CO2H - Human RBC (70% hemolysis at 100microM); C terminal: NH2 - Human RBC (<60% hemolysis at 100microM) |
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| Validated : | Experimentally validated | |||||||||
| Comment : | Inactive against A.fumigatus(250microg/ml), C.albicans(1000microg/ml); Refer PubMed ID - 16563706: C terminal: CO2H | |||||||||
| AMP Family : | Cathelicidin | |||||||||
| Signature : |
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| Length : | 13 | |||||||||
Sequence: |
VRRFPWWWPFLRR | |||||||||
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