CAMPSQ156
Title : Prepromelittin-related peptide
GenInfo Identifier : 154347368
Source : Rana tagoi [Tago frog]
Taxonomy : Animalia, Amphibia
UniProt: A7BJK6
PubMed : 12804591, 35055066
Activity : Antibacterial, Antifungal, Anticancer, Antiviral
Gram Nature : Gram +ve, Gram -ve
Target :
[ Refer Pubmed ID 12804591: S. aureus ( MIC = 3. 5 microM ), E. coli ( MIC = 20 microM ), C. albicans ( MIC = 19 microM ), EL4 T-lymphoma cells ( MIC = 14 microM ) ], [ Refer Pubmed ID 35055066: Alpha coronavirus (HCoV-229E), Measles virus, Human parainfluenza virus type-2, Beta coronavirus (SARS-CoV-2), Poliovirus type 1 ]
Hemolytic Activity :
Human erythrocytes (8 microM), L929 fibroblasts (20 microM)
Validated : Experimentally validated
Pfam : PF03032 : FSAP_sig_propep ( Brevenin/esculentin/gaegurin/rugosin family )
PF01372 : Melittin ( Melittin )
InterPro : IPR004275 : Brevinin.
IPR002116 : Melittin/Api_allergen.
AMP Family : Melittin
Signature :
ID Type Pattern / HMM
MelittinH23_2 HMM
MelittinH_5 HMM
MelittinP23_2 Pattern I-G-S-I-L-G-A-L-A-x-G-L-P-T-L-I-S-W-I-K-N-R
MelittinP_5 Pattern G-L-P-[AT]-L-I-S-W-I-K
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular component Extracellular region IEA
GO:0004860 Molecular function Protein kinase inhibitor activity IEA
GO:0050830 Biological process Defense response to Gram-positive bacterium IEA
GO:0006955 Biological process Immune response IEA
GO:0005576 Cellular component Extracellular region IEA
GO:0004860 Molecular function Protein kinase inhibitor activity IEA
GO:0050830 Biological process Defense response to Gram-positive bacterium IEA
Length : 23
Sequence:
 AIGSILGALAKGLPTLISWIKNR

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