Temporin

Temporins show some sequence similarity to hemolytic peptides isolated from Vespa venom [PMID: 6206053]. Natural and synthetic temporins have antibacterial activity against gram-positive bacteria with no hemolytic activtiy. Temporins are one of the smallest antibacterial peptides found in nature [PMID: 9022710].

The below sequences were used to create Temporin sequence signatures:

> TemporinH16_6 | CAMPSQ2172 | C5H3Z4 | 194294269
 FTMKKSLLLLFFLGTINLSLCEQERNAEEERRDDLGERQAEVEKR
> TemporinH16_6 | CAMPSQ2177 | C5H0D8 | 167888506
 MFTLKKSLLLLFFLGTINLSLCEQERNAEEERRDEPDERNAEVEKRFFPIVGKLLSGLSG
LLGK
> TemporinH16_6 | CAMPSQ2178 | C5H0D7 | 167888504
 MFTLKKSLLLLFFLGTINLSLCEQERNAEEERRDEPDERNAEVEKRFFPIVGKLLFGLSG
LLGK
> TemporinH16_6 | CAMPSQ2179 | C5H0D6 | 167888502
 MFTMKKSLLLLFFLGTIHLSLCEQERNAEEERRDDLGERQAEVEKRFLPIAGKLLSGLSG
LLGK
> TemporinH16_6 | CAMPSQ2409 | E1AXG2 | 304442822
 TMKKSLLLLFFLGTINLSLCEQERNAEEERRDDLGERQAEVEKR
> TemporinH16_6 | CAMPSQ4069 | K7ZAL9 | 425872843
 FLPIVGKLLSGLSGLLGK
> TemporinH16_6 | CAMPSQ6518 | Q2PGA7 | 84468535
 MFTLKKSLLLLFFLGTINLSLCEEERDADEEERRDDPEEGDVEVEKRAVDLAKIANKVLS
SLFGK

The below sequences were retrieved using Temporin sequence signatures:

> BrevininH_224, BrevininH17_7, BrevininH20_14, BrevininH23_6, BrevininH24_87, GaegurinH_13, GaegurinH24_7, TemporinH19_2 | CAMPSQ362 | P82905 | 32469601
 FLPAIVGAAGKFLPKIFCAISKKC
> TemporinH14_15 | CAMPSQ442 | P82831 | 41018246
 NFLGTLINLAKKIM
> TemporinH16_7, TemporinP16_7 | CAMPSQ444 | P82848 | 41018248
 FLPIVGKLLSGLL
> TemporinH16_7, BrevininH_224, BrevininH22_2 | CAMPSQ2173 | C5H0E2 | 167888514
 MFTLKKSLLLLFFLGTINLSLCEQERNAEEERRDDLGERQAEVEKRFFPIVGKLLSG
> TemporinH16_7, BrevininH_224, BrevininH22_2, TemporinP16_7 | CAMPSQ2174 | C5H0E1 | 167888512
 MFTLKKSLLLLFFLATINLSFCEQERNAEEERRDEPDERNAEVEKRFFPIVGKLLFGLLG
K
> TemporinH16_7, BrevininH_224, BrevininH22_2, TemporinP16_7 | CAMPSQ2175 | C5H0E0 | 167888510
 MFPLKKSLLLLFFLATINLSLCEQERNAEEERRDEPDERNAEVEKRFFPIVGKLLSGLLG
K
> TemporinH16_7, BrevininH_224, BrevininH22_2, TemporinP16_7 | CAMPSQ2176 | C5H0D9 | 167888508
 MFTLKKSLLLLFFLGTINLSLCEQERNAEEERRDDLGERQAEVEKRFFPIVGKLLFGLFG
LLGK
> TemporinH16_7, BrevininH_224, BrevininH22_2, TemporinP16_7 | CAMPSQ2177 | C5H0D8 | 167888506
 MFTLKKSLLLLFFLGTINLSLCEQERNAEEERRDEPDERNAEVEKRFFPIVGKLLSGLSG
LLGK
> TemporinH16_7, BrevininH_224, BrevininH22_2, TemporinP16_7 | CAMPSQ2178 | C5H0D7 | 167888504
 MFTLKKSLLLLFFLGTINLSLCEQERNAEEERRDEPDERNAEVEKRFFPIVGKLLFGLSG
LLGK
> TemporinH16_7, BrevininH_224, BrevininH22_2, TemporinP16_7 | CAMPSQ2179 | C5H0D6 | 167888502
 MFTMKKSLLLLFFLGTIHLSLCEQERNAEEERRDDLGERQAEVEKRFLPIAGKLLSGLSG
LLGK
> TemporinH16_7, BrevininH_224, BrevininH22_2, TemporinP16_7 | CAMPSQ2413 | E1AWE0 | 304442754
 FLPIVGKLLSGLF
> TemporinH16_7, BrevininH_224, BrevininH22_2, TemporinP16_7 | CAMPSQ2423 | E1AWD8 | 304442750
 TLKKPLLVLFFLATINLSLC
> TemporinH16_7, BrevininH_224, BrevininH22_2, TemporinP16_7 | CAMPSQ15501 | A0SN45 |
MFTLKKSLLLLFFLGTINLSLCEQERNAEEERRDEPDERNAEVEKRFLPIVGKLLSGLSG
LLGK
> TemporinH17_8, BrevininH_224, BrevininH22_2 | CAMPSQ15666 | C3RT22 |
MFTMKKSLLLLFFLGAINLPLCQEERNAEEERRDGDDEGSVEVQKRFFPLLFGALSSMMP
KLFGK
> TemporinH16_7, BrevininH_224, BrevininH22_2, TemporinP16_7 | CAMPSQ15691 | E1B248 |
MFTLKKPLLLLFFLGTINLSLCEQERNAEEERRDEPDERNAEVEKRFLPIVGKLLSGLLG
K
> TemporinH19_2, BrevininH_224, BrevininH22_2, TemporinP19_2 | CAMPSQ15727 | E7EKJ5 |
MFTTKKSLLLLFFLGTINLSLCQEERNAEEERRDGDDEGGVEVQKRFFPFLLGALGSLLP
KIFGK
> TemporinH15_4, BrevininH_224, BrevininH22_2 | CAMPSQ15728 | E7EKJ6 |
MFTLKKTLLLLFFLGTINLSLCEEERNAEEERRDGDDEMDVEVKKRFITGLIGGLMKALG
K
> TemporinH15_4, BrevininH_224, BrevininH22_2 | CAMPSQ15729 | E7EKJ7 |
MFTLKKTLLLLFFLGTINLSLCEEERNAEEERRDGDDEMDVEVKKRFISGLIGGLMKALG
K
> TemporinH15_4, BrevininH_224, BrevininH22_2 | CAMPSQ15730 | E7EKM1 |
MFTLKKTLLLLFFLGTINLSLCEEERNAEEERRDGDDEMDVEVKKRFITGLISGLMKALG
K
> TemporinH16_7 | CAMPSQ15892 | P0DTU0 |
FLPIVGKSLSGLSGKL
> TemporinH16_7, BrevininH_224, BrevininH22_2, TemporinP16_7 | CAMPSQ15893 | P0DTU1 |
MFPLKKSLLLLFFLATINLSLCEQERNAEEERRDEPDERNAEVEKRFLPIVGKLLSGLSG
LSGK
© 2022, Biomedical Informatics Centre, NIRRCH, Mumbai