Moricin

Moricin is a antibacterial peptide that is highly basic. The structure of moricin reveals that it is comprised of a long alpha-helix. The N terminus of the helix is amphipathic, and the C terminus of the helix is predominately hydrophobic. The amphipathic N-terminal segment of the alpha- helix is mainly responsible for the increase in permeability of the bacterial membrane which kills the bacteria [PMID: 11997013].

The below sequences were used to create Moricin sequence signatures:

> MoricinH_16, MoricinP_16 | CAMPSQ146 | | 146737990
KVNVNAIKKGGKAIGKGFKVISAASTAHDVYEHIKNRRH
> MoricinH_16, MoricinP_16 | CAMPSQ147 | A5JSU6 | 146737992
GKIPVKAIKKGGQIIGKALRGINIASTAHDIISQFKPKKKKNH
> MoricinH_16, MoricinP_16 | CAMPSQ148 | A5JSU7 | 146737994
KVPIGAIKKGGKIIKKGLGVIGAAGTAHEVYSHVKNRH
> MoricinH_16, MoricinP_16 | CAMPSQ149 | A5JSU8 | 146737996
KVPIGAIKKGGKIIKKGLGVLGAAGTAHEVYNHVRNRQ
> MoricinH_16, MoricinP_16 | CAMPSQ150 | A5JSU9 | 146737998
KVPIGAIKKGGKIIKKGLGVIGAAGTAHEVYSHVKNRQ
> MoricinH_16, MoricinP_16 | CAMPSQ151 | A5JSV0, A5JSV1 | 146738000, 146738002
KVPVGAIKKGGKAIKTGLGVVGAAGTAHEVYSHIRNRH
> MoricinH_16, MoricinP_16 | CAMPSQ152 | A5JSV2 | 146738004
KGIGSALKKGGKIIKGGLGALGAIGTGQQVYEHVQNRQ
> MoricinH_16, MoricinP_16 | CAMPSQ1027 | Q7YZB4 | 159163502
GKIPVKAIKKAGAAIGKGLRAINIASTAHDVYSFFKPKHKKK
> MoricinH_16, MoricinP_16 | CAMPSQ1032 | Q86MA1 | 170784960
GKIPVKAIKQAGKVIGKGLRAINIAGTTHDVVSFFRPKKKKH
> MoricinH_16, MoricinP_16 | CAMPSQ1090 | P82818, O96059 | 20138941, 1246017
AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH
> MoricinH_16, MoricinP_16 | CAMPSQ1252 | P83416 | 25091528
GKIPIGAIKKAGKAIGKGLRAVNIASTAHDVYTFFKPKKRH
> MoricinH_16, MoricinP_16 | CAMPSQ1657 | P82818 | 21465926
AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKA
> MoricinH_16, MoricinP_16 | CAMPSQ2910 | |
KVNANAIKKGGKAIGKGFKVISAASTAHDVYEHIKNRRH
> MoricinH_16, MoricinP_16 | CAMPSQ10738 | |
APKVNVNALKKGGRVIKKGLGVIGAAGTAHEVYNHVRNRNQG
> MoricinH_16, MoricinP_16 | CAMPSQ10739 | |
APKVNVNALRKGGRVIRKGLGVIGAAGTAHEVYNHVRNRNQG
> MoricinH_16, MoricinP_16 | CAMPSQ10740 | |
APKVNVNALKKGGHVIKKGLGVIGAAGTAHEVYNHVRNRNQG

The below sequences were retrieved using Moricin sequence signatures:

> MoricinH_16, MoricinP_16 | CAMPSQ1032 | Q86MA1 | 170784960
GKIPVKAIKQAGKVIGKGLRAINIAGTTHDVVSFFRPKKKKH
> MoricinH_16, MoricinP_16 | CAMPSQ1090 | P82818, O96059 | 20138941, 1246017
AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH
> MoricinH_16, MoricinP_16 | CAMPSQ1252 | P83416 | 25091528
GKIPIGAIKKAGKAIGKGLRAVNIASTAHDVYTFFKPKKRH
> MoricinH_16, MoricinP_16 | CAMPSQ1657 | P82818 | 21465926
AKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKA
> MoricinH_16, MoricinP_16 | CAMPSQ15778 | O96059 |
MNILKLFFVFIVAMSLVSCSTAAPAKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLK
PKKRKH
© 2022, Biomedical Informatics Centre, NIRRCH, Mumbai