Clavanin

This family consists of clavanin proteins from the haemocytes of the invertebrate Styela clava (Sea squirt), a solitary tunicate. The family is made up of four alpha-helical antimicrobial peptides, clavanins A, B, C and D. The tunicate peptides resemble magainins in size, primary sequence and antibacterial activity. Synthetic clavanin A displays comparable antimicrobial activity to magainins and cecropins. The presence of alpha-helical antimicrobial peptides in the haemocytes of a urochordate suggests that such peptides are primeval effectors of innate immunity in the vertebrate lineage [PMID: 9001389].

The below sequences were used to create Clavanin sequence signatures:

> ClavaninH23_5, ClavaninH_5, ClavaninP23_5, ClavaninP_5 | CAMPSQ346 | P80710 | 3121854
VFQFLGKIIHHVGNFVHGFSHVF
> ClavaninH23_5, ClavaninH_5, ClavaninP23_5, ClavaninP_5 | CAMPSQ347 | O18493 | 3121863
VFHLLGKIIHHVGNFVYGFSHVF
> ClavaninH23_5, ClavaninH_5, ClavaninP23_5, ClavaninP_5 | CAMPSQ348 | P80711 | 3121864
VFQFLGRIIHHVGNFVHGFSHVF
> ClavaninH23_5, ClavaninH_5, ClavaninP23_5, ClavaninP_5 | CAMPSQ349 | P80713 | 3121865
AFKLLGRIIHHVGNFVYGFSHVF
> ClavaninH23_5, ClavaninH_5, ClavaninP23_5, ClavaninP_5 | CAMPSQ572 | O97395 | 67460433
FLRFIGSVIHGIGHLVHHIGVAL

The below sequences were retrieved using Clavanin sequence signatures:

> ClavaninH_5, ClavaninH23_5, ClavaninP_5, ClavaninP23_5 | CAMPSQ346 | P80710 | 3121854
VFQFLGKIIHHVGNFVHGFSHVF
> ClavaninH_5, ClavaninH23_5, ClavaninP_5, ClavaninP23_5 | CAMPSQ347 | O18493 | 3121863
VFHLLGKIIHHVGNFVYGFSHVF
> ClavaninH_5, ClavaninH23_5, ClavaninP_5, ClavaninP23_5 | CAMPSQ348 | P80711 | 3121864
VFQFLGRIIHHVGNFVHGFSHVF
> ClavaninH_5, ClavaninH23_5, ClavaninP_5, ClavaninP23_5 | CAMPSQ349 | P80713 | 3121865
AFKLLGRIIHHVGNFVYGFSHVF
> ClavaninH_5, ClavaninH23_5, ClavaninP_5, ClavaninP23_5 | CAMPSQ572 | O97395 | 67460433
FLRFIGSVIHGIGHLVHHIGVAL
> ClavaninH_5, ClavaninH23_5, ClavaninP_5, ClavaninP23_5 | CAMPSQ1816 | O18492 | 3121862
LFKLLGKIIHHVGNFVHGFSHVF
© 2022, Biomedical Informatics Centre, NIRRCH, Mumbai