CAMPR4 (Collection of Anti-Microbial Peptides) has been created to expand and accelerate antimicrobial peptide (AMP) based studies by providing curated information on natural and synthetic AMPs. Recent years have seen an exponential rise in the discovery and design of natural and synthetic AMPs. Synthetic AMPs differ from the natural ones in their physical and chemical properties and needs dedicated algorithm for prediction and rational design of novel AMPs.

CAMPR4 contains information on the AMP sequence, protein definition, accession numbers, activity, source organism, target organisms, protein family descriptions, N and C terminal modifications and links to databases like UniProt, PubMed and other antimicrobial peptide databases are provided for the benefit of users. Synthetic AMPs being dissimilar from natural AMPs owing to their modified amino acid composition, dedicated prediction algorithms for predicting natural and synthetic AMPs are provided. Additionally, the database also provides tools for sequence alignment, pattern creation, pattern and HMM-based search.

Comprehensive documentation of the database can be obtained from the Help page.

This work has been funded by grants from the Science and Engineering Research Board (SERB), India, Department of Biotechnology (DBT), India and Indian Council of Medical Research (ICMR).


Sequences

Structures

Patents

Signatures

Natural AMPs: 11827
Synthetic AMPs: 12416

AMP structures: 933

Patents: 2143

Patterns: 84
HMMs: 179


Citation :

Gawde U, Chakraborty S, Waghu F H, Barai R S, Khanderkar A, Indraguru R, Shirsat T, Idicula-Thomas S. CAMPR4: a database of natural and synthetic antimicrobial peptides. Nucleic Acids Res, 2022. https://doi.org/10.1093/nar/gkac933


CAMPR3 can be accessed here....


Previous Citations :

  1. Waghu FH, Barai RS, Gurung P, Idicula-Thomas S. CAMPR3: a database on sequences, structures and signatures of antimicrobial peptides, Nucleic Acids Res. Volume 44, Issue D1, 4 January 2016, Pages D1094–D1097, https://doi.org/10.1093/nar/gkv1051. PubMed PMID: 26467475.

  2. Waghu FH, Idicula-Thomas S. Collection of antimicrobial peptides database and its derivatives: Applications and beyond. Protein Sci. 2020 Jan;29(1):36-42. https://doi.org/10.1002/pro.3714. Epub 2019 Sep 30. PubMed PMID: 31441165.

  3. Waghu FH, Gopi L, Barai RS, Ramteke P, Nizami B, Idicula-Thomas S. CAMP: Collection of sequences and structures of antimicrobial peptides. Nucleic Acids Res. 2014 Jan 1;42(1):D1154-8, https://doi.org/10.1093/nar/gkt1157. Epub 2013 Nov 21. PubMed PMID: 24265220.

  4. Thomas S, Karnik S, Barai RS, Jayaraman VK, Idicula-Thomas S. CAMP: a useful resource for research on antimicrobial peptides. Nucleic Acids Res. 2010 Jan;38(Database issue):D774-80, https://doi.org/10.1093/nar/gkp1021. Epub 2009 Nov 18. PubMed PMID: 19923233.

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