| CAMPSQ274 |
| Title : |
Neutrophil antibiotic peptide NP-4 precursor |
| GenInfo Identifier : |
2494048 |
| Source : |
Rattus norvegicus [Rat] |
| Taxonomy : |
Animalia, Mammals |
| UniProt: |
Q62714 |
| PubMed : |
2543629 |
| Activity : |
Antibacterial, Antifungal, Antiviral |
| Gram Nature : |
Gram +ve, Gram -ve |
| Target : |
S. aureus 502A ( MIC = 50 microg/ml ), C. neoformans ( MIC = 10 microg/ml ), A.calcoaceticus ( MIC = 50 microg/ml ), E.coli ML-35, C.albicans |
| Validated : |
Experimentally validated |
| Pfam : |
PF00323 : Defensin_1 ( Mammalian defensin )
PF00879 : Defensin_propep ( Defensin propeptide )
|
| InterPro : |
IPR016327 : Alpha-defensin.
IPR006080 : Defensin_beta/neutrophil.
IPR002366 : Defensin_propep.
IPR006081 : Mammalian_defensins.
|
| AMP Family : |
Defensin |
| Signature : |
| ID |
Type |
Pattern / HMM |
|
DefensinH32_11 |
HMM |
 |
|
| Gene Ontology : |
| GO ID |
Ontology |
Definition |
Evidence |
| GO:0042582 |
Cellular component |
Azurophil granule |
ISO |
| GO:0005737 |
Cellular component |
Cytoplasm |
TAS |
| GO:0005615 |
Cellular component |
Extracellular space |
IBA |
| GO:0042802 |
Molecular function |
Identical protein binding |
ISO |
| GO:0042803 |
Molecular function |
Protein homodimerization activity |
ISO |
| GO:0019731 |
Biological process |
Antibacterial humoral response |
ISO |
| GO:0019732 |
Biological process |
Antifungal humoral response |
ISO |
| GO:0061844 |
Biological process |
Antimicrobial humoral immune response mediated by antimicrobial peptide |
ISO |
| GO:0019730 |
Biological process |
Antimicrobial humoral response |
ISO |
| GO:0071222 |
Biological process |
Cellular response to lipopolysaccharide |
IBA |
| GO:0006952 |
Biological process |
Defense response |
TAS |
| GO:0042742 |
Biological process |
Defense response to bacterium |
ISO |
| GO:0050832 |
Biological process |
Defense response to fungus |
ISO |
| GO:0050829 |
Biological process |
Defense response to Gram-negative bacterium |
ISO |
| GO:0050830 |
Biological process |
Defense response to Gram-positive bacterium |
ISO |
| GO:0045087 |
Biological process |
Innate immune response |
ISO |
| GO:0002227 |
Biological process |
Innate immune response in mucosa |
IBA |
| GO:0031640 |
Biological process |
Killing of cells of other organism |
IEA |
| GO:0051673 |
Biological process |
Membrane disruption in other organism |
IBA |
|
| Length : |
31 |
Sequence: |
ACYCRIGACVSGERLTGACGLNGRIYRLCCR |
