Caerin

This family consists of several caerin 1 proteins from Litoria species, Australian tree frogs. The caerin 1 peptides are among the most powerful of the broad-spectrum antibiotic amphibian peptides [PMID: 12717721]. These peptides are excreted from amphibian skin, and can interact with and disrupt bacterial membranes, leading to the permeabilisation of the cell membrane.

The below sequences were used to create Caerin sequence signatures:

>CAMPSQ3327
GLLGAMFKVASKVLPHVVPAITEHF
>CAMPSQ3689
GLFGILGSVAKHVLPHVIPVVAEHL
>CAMPSQ493
GLFKVLGSVAKHLLPHVAPVIAEKL
>CAMPSQ718
GLFKVLGSVAKHLLPHVAPVIAEK
>CAMPSQ92
GLFSVLGSVAKHLLPHVAPIIAEKL
>CAMPSQ94
GLFKVLGSVAKHLLPHVAPIIAEKL
>CAMPSQ93
GLFSVLGSVAKHLLPHVVPVIAEKL
>CAMPSQ383
GLFKVLGSVAKHLLPHVVPVIAEK
>CAMPSQ796
GLFSVLGSVAKHVVPRVVPVIAEHLG
>CAMPSQ384
GLFGVLGSIAKHVLPHVVPVIAEKL
>CAMPSQ492, CAMPSQ1140, CAMPSQ4491
GLFSVLGAVAKHVLPHVVPVIAEKL
>CAMPSQ719
GLFSVLGAVAKHVLPHVVPVIAEK
>CAMPSQ29, CAMPSQ4489
GLLSVLGSVAKHVLPHVVPVIAEKL
>CAMPSQ494
GLLSVLGSVAKHVLPHVVPVIAEHL
>CAMPSQ2584
LLSVLGSVAKHVLPHVVPVIAEHL

The below sequences were retrieved using Caerin sequence signatures:

> CAMPCaeP, CAMPCaeH | CAMPSQ29 | P82104 | 11131738
GLLSVLGSVAKHVLPHVVPVIAEKL
> CAMPCaeP, CAMPCaeH | CAMPSQ92 | P0C2A6 | 122063381
GLFSVLGSVAKHLLPHVAPIIAEKL
> CAMPCaeP, CAMPCaeH | CAMPSQ93 | P0C2A7 | 122063382
GLFSVLGSVAKHLLPHVVPVIAEKL
> CAMPCaeP, CAMPCaeH | CAMPSQ94 | P0C2A8 | 122063383
GLFKVLGSVAKHLLPHVAPIIAEKL
> CAMPCaeH | CAMPSQ234 | P82066 | 20138937
GLFGVLAKVAAHVVPAIAEHF
> CAMPCaeH | CAMPSQ235 | P82067 | 20138938
GLFGVLAKVASHVVPAIAEHFQA
> CAMPCaeP, CAMPCaeH | CAMPSQ383 | P81251 | 3913369
GLFKVLGSVAKHLLPHVVPVIAEK
> CAMPCaeP, CAMPCaeH | CAMPSQ384 | P81252 | 3913370
GLFGVLGSIAKHVLPHVVPVIAEKL
> CAMPCaeP, CAMPCaeH | CAMPSQ492 | P62546 | 50401860
GLFSVLGAVAKHVLPHVVPVIAEKL
> CAMPCaeP, CAMPCaeH | CAMPSQ493 | P62548 | 50401862
GLFKVLGSVAKHLLPHVAPVIAEKL
> CAMPCaeP, CAMPCaeH | CAMPSQ494 | P62568 | 50401866
GLLSVLGSVAKHVLPHVVPVIAEHL
> CAMPCaeP, CAMPCaeH | CAMPSQ718 | P62549 | 50401863
GLFKVLGSVAKHLLPHVAPVIAEK
> CAMPCaeP, CAMPCaeH | CAMPSQ719 | P62547 | 50401861
GLFSVLGAVAKHVLPHVVPVIAEK
> CAMPCaeP, CAMPCaeH | CAMPSQ796 | Q800R9 | 29123260
GLFSVLGSVAKHVVPRVVPVIAEHLG
> CAMPCaeP, CAMPCaeH | CAMPSQ1213 | P62569 | 50401867
GLLSVLGSVAKHVLPHVVPVIAEHL
> CAMPCaeP, CAMPCaeH | CAMPSQ1217 | P62544 | 50401858
GLLSSLSSVAKHVLPHVVPVIAEHL
> CAMPCaeP, CAMPCaeH | CAMPSQ1219 | P62545 | 50401859
GLLSSLSSVAKHVLPHVVPVIAEHL
> CAMPCaeH | CAMPSQ1226 | P56230 | 3023545
GLLSVLGSVVKHVIPHVVPVIAEHL
> CAMPCaeH | CAMPSQ1227 | P56228 | 3023543
GLLSVLGSVAQHVLPHVVPVIAEHL
> CAMPCaeP, CAMPCaeH | CAMPSQ1228 | P56227 | 3023542
GLLGVLGSVAKHVLPHVVPVIAEHL
> CAMPCaeH, CAMPCaeP | CAMPSQ1305 | Q800R6 | 29123266
SVLGKSVAKHLPHVVPVIAEKT
> CAMPCaeH | CAMPSQ1306 | Q800R7 | 29123264
GLLSVLGSLKLIVPHVVPLIAEHL
> CAMPCaeP, CAMPCaeH | CAMPSQ1307 | Q800R8 | 29123262
GLFGILGSVAKHVLPHVVPVIAEHS
> CAMPCaeP, CAMPCaeH | CAMPSQ2584 | P86484 | 296439547
LLSVLGSVAKHVLPHVVPVIAEHL
> CAMPCaeP, CAMPCaeH | CAMPSQ2749 | P81252 |
GLFGVLGSIAKHVLPHVVPVIAEK
> CAMPCaeH | CAMPSQ2750 | P82066 |
GLFVGVLAKVAAHVVPAIAEHF
> CAMPCaeH | CAMPSQ2751 | P82067 |
GLFVGLAKVAAHNNPAIAEHFQA
> CAMPCaeP, CAMPCaeH | CAMPSQ4489 | P86502 |
GLLSVLGSVAKHVLPHVVPVIAEKL
> CAMPCaeP, CAMPCaeH | CAMPSQ4490 | Q800R2 |
SVLGSVAKHVLPHVVPVIAEHL
> CAMPCaeP, CAMPCaeH | CAMPSQ4491 | P86503 |
GLFSVLGAVAKHVLPHVVPVIAEKL
> CAMPCaeP, CAMPCaeH | CAMPSQ5055 | B5AKW4 | 195765011
MAFLKKSLFLVLFLGFVSVSICEEEKRQEDEDEHVEEGENQEEGSEEKRGLLSVLGSVAK
HVLPHVVPVIAEHLG
> CAMPCaeP, CAMPCaeH | CAMPSQ5056 | B5AKW5 | 195765013
MAFLKKSLFLGLFLGFVSVSICEEEKRQEDEDEHDEEGENQEEGSEEKRGLLSVLGSVAK
HVLPHVVPVIAEHLG
> CAMPCaeP, CAMPCaeH | CAMPSQ6446 | P86501 | 298351621
GLLSVLGSVAKHVLPHVVPVIAEHL
> CAMPCaeH | CAMPSQ7006 | | 738226
GLLSVLGSVAKHVLPHVVPVIAEHL
> CAMPCaeH | CAMPSQ7007 | | 738227
GLLSVLLGSVAKHVLPHVVPVIAEHL
2015, © Biomedical Informatics Centre, NIRRH, Mumbai